Chinese Journal of Oceanology and Limnology

, Volume 23, Issue 2, pp 226–229 | Cite as

Isolation and pharmacological activities of bromophenols fromRhodomela confervoides

  • Han Lijun
  • Xu Nianjun
  • Shi Jiangong
  • Yan Xiaojun
  • Zheng Chengkui


Four bromophenols were isolated from the extract of marine red alga,Rhodomela confervoides by column chromatography and HPLC methods. By means of spectroscopic methods inclding IR, MS, 1D, and 2D-NMR techniques, their structures were elucidated as (1) 3-bromo-4,5-dihydroxy benzoic acid methyl ester; (2) bis (2,3-dibromo-4,5-dihydroxybenzyl) ether; (3) 3,4-dibromo-5-(methoxymethyl)-1,2-benzenediol and (4) 3-bromo-4,5-dihydroxy-benzaldehyde. Compound 1 was first isolated from the algae in nature, and 1, 4 were found to have selective cytotoxic activities against KB, Bel 7402 and A549 cells, 2 showed powerful antibacterial activities againstStaphylococcus aurens andPseudomonas aeruginosa.

Key words

Rhodomela confervoides bromophenol antitumor antibacterial 


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Copyright information

© Science Press 2005

Authors and Affiliations

  • Han Lijun
    • 1
  • Xu Nianjun
    • 1
  • Shi Jiangong
    • 2
  • Yan Xiaojun
    • 3
  • Zheng Chengkui
    • 1
  1. 1.Institute of OceanologyChinese Academy of SciencesQingdaoChina
  2. 2.Institute of Marina MedicaChinese Academy of Medical SciencesBeijingChina
  3. 3.Key Laboratory of Marine BiotechnologyNingbo UniversityNingboChina

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