Abstract
The concentrations of total serum IgA and IgG of 267 patients with different primary malignant tumors were measured by ELISA. Total serum IgA increased by 30% to 40% in patients with malignancies associated with mucous membranes (nasopharyngeal, gastrointestinal and bronchial carcinomas), while the change in total serum IgG was negligible. Although, the changes in Ig level could be influenced by many host factors, these data call attention to the potential indicative role of total serum IgA levels. Further studies are required to establish links between serum IgA levels and stages of tumor growth or tumor progression in order to use these values as prognostic factors.
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References
Brooks JJ and Carolin SE: Immimoreactive Secretory Component of IgA Human Tissues and Tumors. Am J Clin Pathol 82:660–665, 1984.
Brown WR and Kloppel TM: The liver and IgA. Immunological. Cell Biological and Clinical Implications. Hepatology 9:763–789, 1989.
Chan CK, Mueller N, Evans A, Harris NL, Comstock GM, Jellum E, Magnos K, Krentreich N, Polk BF and Vogelman J: Epstein Barr virus antibody patterns preceding the diagnosis of nasopharyngeal carcinoma. Cancer Causes Control 2:125–131, 1991.
Delacroix DE, Jonard DP and Vaerman JP: Serum IgM-bound secretory component (SIgM) in liver diseases. Comparative molecular state of the secretory component in serum and bile. J Immunol 129:133–138, 1982.
Gong YZ, Zhang XY and Chen XT: In vitro synthesis of SIgA and CEA and their relationship in gastric cancer tissue. Chung-Hua-Chung-Liu-Tsa-Chin. 10:184–187, 1988.
Kanda T, Onoda T, Zanma S, Yasugi T, Furuno A, Watenabe S and Kawana T: Indepedent association of antibodies against human Papilloma virus type 16 E1/E4 and E7 proteins with cervical cancer. Virology 190:724–776, 1992.
Keren FD: Mucosal IgA elaboration. Critical Reviews in Clinical Lab Sci 27:158–176, 1989.
Kvale D, Rognum TO and Brundtzaeg P: Elevated Levels of Secretory Immunoglobulins A and M in Serum of Patients With Large Bowel Carcinoma Indicate Liver Metastasis. Cancer 59:203–207. 1987.
Lehtinen M, Leminen A, Kuoppala T, Tikkainen M, Lehtinen T, Lehtovirta P, Punonen R, Veterinen E and Pavonen J: Preand posttreament serum antibody responses to HPV 16 E2 and HSV 2 ICP8 proteins in women with cervical carcinoma. J Med Virol 37:180–186, 1992.
Littler E, Baylis SA, Zeug Y, Conway MJ, Muckett M andArrand JR: Diagnosis of Nasopharyngeal Carcinoma by Means of Recombinant Epstein-Barr Virus Proteins. Lancet 337:685–689, 1991.
Lung ML, Lam WP, Sham J, Chay D, Yung-Sheng Y and Guo HY: Detection of prevalence of the “f” variant of Epstein-Barr virus in southern China. Virology 185:67–71, 1991.
Rudhukrishna PM, Baluram P.Hureendran NK, Bindu S, Abraham T, Padmanabham TK and Nair MK: Immune reactive proteins as prognostic and clinical markers in malignant cervical neoplasia. J Cancer Res Clin Oncol 115:583–691, 1989.
Russell MW, Lue Van den Wall Bake AWL,Moldoveunu Y and Mestecky J: Molecular heterogenity of human IgA antibodies during an immune reponse. Rev Clin Exp Immunol 87:1–6. 1992.
Smyslova VN: Possibilities of Prognosis in Cancer of the Transverse Colon and Rectum using CEA, AFP, and Immunoglobulins A. M, and G. Vopr Oncol 33:42–48. 1987.
Wolf HM, Fisher MB, Pnebringer H, Smastag A, Vogel E andEibl MM: Human serum IgA downregulates the release of inflammatory cytokines (tumor necrosis factor - alfa, interleukin-6) in human monocytes. Blood 83:1278–1288, 1994.
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Hrzenjak, T.M., Roguljic, A., Efenberger-Marinculic, P. et al. Total IgA and IgG in sera of patients with different primary malignancies. Pathol. Oncol. Res. 2, 66–68 (1996). https://doi.org/10.1007/BF02893953
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DOI: https://doi.org/10.1007/BF02893953