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Possible role of formaldehyde in the apoptotic and mitotic effect of 1-methyl-ascorbigen

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Pathology & Oncology Research

Abstract

PC-3 human prostate carcinoma cells were treated with 100 ug/ml 1-methyl-ascorbigen (Me-Asc). This treatment resulted in a significant decrease in tumor cell number in parallel with an increase in apoptotic cells. The formaldehyde (HCHO) level in the culture medium was also increased. Dimedone (Di), a known capture molecule forming formaldemethone with HCHO, applied simultaneously with Me-Asc in 10 ug/ml doses diminished the apoptosis-inducing effect of Me-Asc. The possible role of in situ generated HCHO in the induction of apoptosis is discussed.

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Authors and Affiliations

  1. 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Pathology, Üllői út 26, 1085, Budapest, Hungary

    Béla Szende

  2. Plant Protection Institute, Hungarian Academy of Sciences, Budapest, Hungary

    Ernő Tyihák

  3. Institute of Organic Chemistry, Lóránd Eötvös University, Budapest, Hungary

    Gyula Szókán & György Kätay

Authors
  1. Béla Szende
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  2. Ernő Tyihák
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  3. Gyula Szókán
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  4. György Kätay
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Szende, B., Tyihák, E., Szókán, G. et al. Possible role of formaldehyde in the apoptotic and mitotic effect of 1-methyl-ascorbigen. Pathol. Oncol. Res. 1, 38–42 (1995). https://doi.org/10.1007/BF02893582

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  • DOI: https://doi.org/10.1007/BF02893582

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