Zusammenfassung
Die glomerulären Veränderungen einer Kaninchen-NTγG bedingten Masugi-Nephritis bei Ratten werden in ihrer Initialphase im zeitlichen Ablauf studiert. 2–12 Std nach der Injektion von NTγG waren hauptsächlich eine Infiltration mit neutrophilen Leukocyten in Glomerulumcapillaren und eine Thrombenbildung vorhanden. In den folgenden 12–72 Std war eine auffallende Monocytenansammlung feststellbar. Diese Monocyten veränderten sich manchmal zu Makrophagen und Riesenzellen. Sie rührten oft direkt an die Lamina rara interna, indem sie die Endothelzellen der Glomerulumcapillaren verdrängten. Erst nach dem Verschwinden dieser Zellen regenerierten Endothelien der Glomerulumcapillaren.
Summary
Two characteristic glomerular changes were noted in the initial (heterologous) phase of rat Masugi nephritis induced by a single intravenous injection of rabbit NTyG. The one is the neutrophil infiltration as has been observed by many investigators. The other is the mononuclear cell (monocyte) accumulation. Both take place independently but consecutively along the glomerular basement membrane. New evidence on accumulation of monocytes is presented. The glomerular changes are summarized as follows:
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(1)
From two to 12 hrs there was a prominent infiltration of neutrophils and platelets together with an enhanced formation of fibrin thrombi in the capillary lumen. At the ultrastructural level the endothelial layer was dislodged and the neutrophils attached to the denuded basement membrane. Degranulation and destructive changes were observed in the neutrophils.
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(2)
From 12 to 72 hrs neutrophil infiltration and clotting substances were rapidly diminished and a large number of monocytes accumulated in the lumen. These monocytes transformed into macrophages and giant cells. Their role in the removal of intraluminal clotting substances is discussed.
Within 72 hrs both thrombotic changes and monocytic reaction disappeared, then the injured endothelial layer was gradually repaired by elongation of the cytoplasm and by mitosis of the endothelial cells. Thus we could confirm that glomerular injury during the initial phase was mostly repaired in a relatively short time.
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This study was partially supported by grants to Dr. A. Okabayashi (Director of Pathology) from the Japanese Ministry of Education. Part of a thesis submitted to School of Medicine, Chiba University, Chiba, Japan, in partial fulfilment of the requirements for the Ph. D. degree in Pathology.
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Shigematstu, H. Glomerular events during the initial phase of rat Masugi nephritis. Virchows Arch. Abt. B Zellpath. 5, 187–200 (1970). https://doi.org/10.1007/BF02893561
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DOI: https://doi.org/10.1007/BF02893561