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Myocardial ultrastructural modification in rat heart-lung preparation failed under two different haemodynamic conditions

Ultrastrukturveränderungen des Herzens in Herz-Lungen-Präparaten bei zwei verschiedenen hämodynamischen Bedingungen

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Virchows Archiv B

Zusammenfassung

Es werden die von zweierlei Herzdekompensationen am Herz-Lungen-Präparat bewirkten ultrastrukturellen Veränderungen des Rattenmyokards untersucht.

Die Herzdekompensation wurde unter den folgenden verschiedenartigen hämodynamischen Arbeitsbedingungen hervorgerufen: 1. beim arteriellen Hochdruck und hohen Herzminutenvolumen („belastungsbedingtes Herzversagen“) oder 2. beim mäßigen arteriellen Blutdruck und mäßigen Herzminutenvolumen („spontanes Herzversagen“).

Im Zusammenhang mit den verschiedenen Arten von Herzdekompensation sind verschiedenartige ultrastrukturelle Veränderungen am Herzmuskel zu beobachten, und zwar: beim „belastungsbedingten Herzversagen“ treten stellenweise Veränderungen an den Mitochondrien hervor, die verschwollen, mit fragmentierten Cristae und heller Matrix erscheinen; beim „spontanen Herzversagen“ sind zahlreiche den Mitochondrien nahe zerstreute Fetttröpfchen vorhanden.

Die Herzdekompensation scheint dem Muskelfibrillenapparat nicht zu schaden.

Die möglichen Zusammenhänge zwischen den obengenannten ultrastrukturellen Veränderungen und den in früheren eigenen Arbeiten beschriebenen Stoffwechseländerungen werden besprochen.

Summary

The ultrastructural alterations of heart muscle cells, induced by two types of cardiac failure in rat heart-lung preparation, have been investigated.

Heart failure was obtained by imposing on the heart two different haemodynamic load conditions: 1) high mean arterial blood pressure and high cardiac output (load failure) or 2) moderate mean arterial blood pressure and moderate cardiac output (spontaneous failure).

Different ultrastructural alterations were observed in the hearts in relation to these different types of heart failure: “load failure” caused patchy alteration of mitochondria that appeared swollen, with broken cristae and pale matrix; “spontaneous failure”, on the other hand, resulted in the appearance of many scattered lipid droplets close to the mitochondria.

Cardiac failure did not appear to affect the myofibrillar apparatus.

The possible relationship between the above ultrastructural alterations and the metabolic changes reported in previous papers are discussed.

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Authors and Affiliations

  1. Institute of Human Physiology, University of Pavia, Italy

    R. Minelli & F. Osculati

  2. Institute of Human Anatomy, University of Pavia, Italy

    R. Minelli & F. Osculati

Authors
  1. R. Minelli
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  2. F. Osculati
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Minelli, R., Osculati, F. Myocardial ultrastructural modification in rat heart-lung preparation failed under two different haemodynamic conditions. Virchows Arch. Abt. B Zellpath. 5, 30–38 (1970). https://doi.org/10.1007/BF02893549

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  • DOI: https://doi.org/10.1007/BF02893549

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