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Primary bone marrow T-cell anaplastic large cell lymphoma with triple m gradient

  • Case Report
  • Published:
Pathology & Oncology Research

Abstract

We present a case of a 60-year-old male patient with primary bone marrow anaplastic large cell lymphoma. He was admitted to the hospital with the symptoms of anemia and fever. There was no evidence of lymphadenopathy or splenomegaly. Immunoelectrophoresis showed the presence of a triple M gradient (double IgM and an IgG), with the IgG and one of the IgM paraproteins functioning as a cryoglobulin. The patient had no hepatitis C virus infection. Bone marrow biopsy showed massive CD30-positive, ALK-negative large lymphoid cell infiltration of T-cell origin with anaplastic morphology. PCR analysis of lymphoid cells separated from the bone marrow demonstrated the presence of a B/T hybrid genotype disorder with no evidence of the t(2;5), nor t(1;2) translocations. The patient entered a period of remission following CHOP chemotherapy. The patient subsequently died of sepsis as a consequence of serious humoral immunodeficiency.

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Abbreviations

PCR:

polymerase chain reaction

IgH:

immunoglobulin heavy chain

TCR:

T-cell receptor

RT-PCR:

reverse transcriptase polymerase chain reaction

ALK:

anaplastic lymphoma kinase

CHOP:

cyclophosphamide-hydroxy epirubicine-oncovin-pred-nisolone

ALCL:

anaplastic large cell lymphoma

HCV:

hepatitis C virus

HBsAg:

hepatitis B surface antigen

MDR:

multi-drug resistance

WHO:

World Health Organization

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Authors and Affiliations

  1. 1st Department of Medicine, University of Pécs, Ifjúság u. 13., H-7624, Pécs, Hungary

    Árpád Szomor & Hajna Losonczy

  2. Institute of Pathology, University of Pécs, Hungary

    László Kereskai

  3. Department of Ophthalmology, University of Pécs, Hungary

    Zsuzsanna Szijártó

  4. Laboratory of Anatomic Pathology, Central Hospital University Purpan, Toulouse, France

    Talal Al Saati & Georges Delsol

Authors
  1. Árpád Szomor
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  2. Talal Al Saati
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  3. Georges Delsol
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  4. László Kereskai
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  5. Zsuzsanna Szijártó
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  6. Hajna Losonczy
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Correspondence to Árpád Szomor.

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Szomor, Á., Saati, T.A., Delsol, G. et al. Primary bone marrow T-cell anaplastic large cell lymphoma with triple m gradient. Pathol. Oncol. Res. 13, 260–262 (2007). https://doi.org/10.1007/BF02893508

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  • DOI: https://doi.org/10.1007/BF02893508

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