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p53 codon 72 polymorphism in basal cell carcinoma of the skin

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Pathology & Oncology Research

Abstract

Basal cell carcinoma (BCC) is the most prevalent cancer in Iran. A common polymorphism at codon 72 of exon 4 of p53 tumor suppressor gene has been reported to be associated with increased inheritable susceptibility to several cancers. In the present study the frequency of p53 codon 72 polymorphism in 91 patients with BCC of skin, compared to 465 healthy normal individuals, was investigated. In total, there was no significant difference in the p53 genotypes between patients and controls. However, there was an apparent increase in theArgl Arg genotype among those BCC patients who had a history of occupational sun exposure, compared to non-exposed patients (46.3% vs. 23.1%, P=0.11). A trend of increase in the frequency ofArg allele among sun-exposed patients was also observed (69.4% vs. 53.8%, P=0.07). Comparison of the genotype frequencies between sunexposed patients and normal controls confirmed the accumulation ofArgl Arg genotype in these patients (46.3% vs. 34.8%, P = 0.07). In addition, the frequency ofArg allele was significantly higher in sunexposed patients compared to controls (69.4% vs. 58.2%, P=0.03). Our results suggest thatArg allele at codon 72 of p53 gene might affect the risk of ultraviolet-induced basal cell carcinoma.

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Authors and Affiliations

  1. Shiraz Institute for Cancer Research (ICR), Shiraz University of Medical Sciences, Shiraz, Iran

    Abdulmohammad Pezeshki, Abbas Ghaderi & Mehrnoosh Doroudchi Ph.D.

  2. Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

    Fatemeh Sari-Aslanl

  3. Department of Immunology, Medical School, Shiraz University of Medical Sciences, P.O. Box: 71345-1798, Shiraz, Iran

    Abbas Ghaderi & Mehrnoosh Doroudchi Ph.D.

Authors
  1. Abdulmohammad Pezeshki
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  2. Fatemeh Sari-Aslanl
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  3. Abbas Ghaderi
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  4. Mehrnoosh Doroudchi Ph.D.
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Correspondence to Mehrnoosh Doroudchi Ph.D..

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Pezeshki, A., Sari-Aslanl, F., Ghaderi, A. et al. p53 codon 72 polymorphism in basal cell carcinoma of the skin. Pathol. Oncol. Res. 12, 29–33 (2006). https://doi.org/10.1007/BF02893428

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  • DOI: https://doi.org/10.1007/BF02893428

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