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Clinical manifestations of genetic instability overlap one another

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Pathology & Oncology Research

Abstract

Cancer syndromes are characteristic associations of specific malignancies with various congenital anomalies. In addition to such diseases, an increased prevalence in general of chromosomal instability, malformations, immunodeficiencies, altered growth and development, and reproductive loss has been observed in both childhood leukemias and solid tumors. The overlap among these congenital disorders suggests their common prenatal, possibly genetic origin and thus the existence of a nonspecific genetic instability leading to various clinical manifestations of disturbancies in cell division. Seeking for related features in family members of a patient with malignancy may be of clinical value in detecting predisposition to cancer.

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Correspondence to Károly Méhes.

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Hungarian Science Foundation (OTKA T-032027) and Hungarian Ministry of Health (ETT 332/2003).

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Méhes, K., Kosztolányi, G. Clinical manifestations of genetic instability overlap one another. Pathol. Oncol. Res. 10, 12–16 (2004). https://doi.org/10.1007/BF02893402

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