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Giant cell fibroblastoma in a 3-year-old boy

Abstract

Giant cell fibroblastoma (GCF) is a rare soft tissue tumor most often discovered during the first two decades of life. We present a case of a 3- year- old boy with a history of a recurrent lesion in the knee, the tumor growth progressively and enlarged to 2.1 cm in the previous two years before diagnosis. It involved the subcutaneous tissue, had infiltrative borders and extended into the superficial dermis. The tumor was surgically excised with free margins. There was no evidence of local recurrence, and a metastatic workup was negative after 10 years of follow up. We review herein the clinicopathologic features, histogenesis, differential diagnosis and relationship to dermatofibrosarcoma protuberans (DFSP).

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References

  1. Shmookler BM, Enzinger FM: Giant cell fibroblastoma: a peculiar childhood tumor. Lab Invest 46:76-xx, 1982.

    Google Scholar 

  2. Shmookler BM, Enzinger FM, Weiss SW: Giant cell fibroblastoma: a juvenile form of dermatofibrosarcoma protuberans. Cancer 64:2154–61, 1989.

    PubMed  Article  CAS  Google Scholar 

  3. Kholova I, Ryska A, Dedic K: Composite tumor consisting of dermatofibrosarcoma protuberans and giant cell fibroblastoma associated with intratumoral endometriosis. Report of a case. Pathol Res Pract 197:263–7, 2001.

    Article  CAS  Google Scholar 

  4. Maeda T, Hirose T, Furuya K, et al: Giant cell fibroblastoma associated with dermatofibrosarcoma protuberans: a case report. Mod Pathol 11:491–5, 1998.

    PubMed  CAS  Google Scholar 

  5. Fletcher CD: Giant cell fibroblastoma of soft tissue: a clinicopathological and immunohistochemical study. Histopathology 13:499–508, 1988.

    PubMed  CAS  Google Scholar 

  6. Weiss SW, Nickoloff BJ: CD 34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol 17:1039. 1993.

    PubMed  CAS  Article  Google Scholar 

  7. Abdul-Karim W, Evans HL, Silva EG: Giant cell fibroblastoma: a report of three cases. Am J Clin Pathol 83:165–70, 1985.

    PubMed  CAS  Google Scholar 

  8. Nguyen CM, Burch JM, Fitzpatrick JE, et al: Giant cell fibroblastoma in a child misdiagnosed as a dermatofibroma. Ped Dermatol 19:28–32, 2002.

    Article  Google Scholar 

  9. Goldblum JR: Giant cell fibroblastoma a report of three cases with histologic and immunohistochemical evidence of a relationship to dermatofibrosarcoma protuberans. Arch Pathol Lab Med 120:1052–55, 1996.

    PubMed  CAS  Google Scholar 

  10. Beham A, Fletcher CDM: Dermatofibrosarcoma protuberans with areas resembling giant cell fibroblastoma: report of two cases. Histopathology 17:165–7, 1990.

    PubMed  Article  CAS  Google Scholar 

  11. Cin PD, Sciot R, De Wever I, et al: Cytogenetic and immunohistochemical evidence that giant cell fibroblastoma is related to dermatofibrosarcoma protuberans. Genes Chromosomes Cancer 15:73, 1996.

    PubMed  Article  CAS  Google Scholar 

  12. Terrier-Lacombe MJ, Guillou L, Maire G, et al: Dermatofibrosarcoma protuberans, giant cell fibroblastoma and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data-a study from the French federation of cancer centers sarcoma group. Am J Surg Pathol 27:27–39, 2003.

    PubMed  Article  Google Scholar 

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Correspondence to Roberto Vargas-Gonzalez.

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Vargas-Gonzalez, R., Solis-Coria, A. Giant cell fibroblastoma in a 3-year-old boy. Pathol. Oncol. Res. 9, 249–251 (2003). https://doi.org/10.1007/BF02893387

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  • DOI: https://doi.org/10.1007/BF02893387

Keywords

  • tumor
  • giant cell
  • giant cell fibroblastoma
  • dermatofibrosarcoma protuberans