Abstract
Urinary cytology reports of 151 patients with histologically verified tumors from the periods 1981– 1985 and 1991–1995 were analyzed. No significant change in the overall sensitivity of tumor detection (76% and 76.8%, respectively) was found. In the group of well-differentiated (G0–G1) tumors, however, 60% of the more recent cases were cytologically positive or suspicious, 23% more than ten years ago. A decrease in the detection rate of G2 tumors in the last period (72% versus 89%) was probably caused by false negative reports due to frequent inflammatory changes in the specimens. Poorly differentiated (G3–G4) transitional cell tumors resulted in a high rate of positive cytological diagnoses (93% in both periods). In cases with negative cytology at clinical suspicion of tumor, repeated sampling increased the detection rate of G0–G1 lesions from 53% up to 60%. Optimal sampling and preparation technique, cytopathologists training and improved follow-up of patients are preconditions of sensitive and specific urinary cytology.
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References
AndrionA and BoffettaP: Diagnostic criteria and terminology in urinary cytology. Cytopathology 5:62–63. 1994.
Billerey C, Lamy B, BittardH, et al: Flow cytometry versus urinary cytology in the diagnosis and follow-up of bladder tumors: critical review of a 5-year experience. World J Urol 11:156–160, 1993.
Chow NH, Tzai TS:Cheng HL, et al: Urinary cytodiagnosis: can it have a different prognostic implication than a diagnostic test? Urol Int 53:18–23, 1994.
Farrow GM: Urine cytology in the detection of bladder cancer: A critical approach. J Occup Med 32:817–821, 1990.
Gamarra MC and ZeinT: Cytologic spectrum of bladder cancer. Urology 23 (Suppl): 23–26, 1984.
Harving N, Petersen SE, MeisenF and WolfH: Urinary cytology in the detection of bladder tumorus. Influence of concomitant urothelial atypia. Scand J Urol Nephrol Suppl. 125:127–131, 1989.
KannanV and BaseS: Low grade transitional cell carcinoma and instrument artifact. A challenge in urinary cytology. Acta Cytol 37:899–902, 1993.
Koss LG: Diagnostic cytology of the urinary tract.Lippincott Raven Publishers, Philadelphia, New York, 1996. pp. 124–148.
MondalA and Banerjee DK: The reliability of urinary cytology in the detection of tumours of urinary bladder. J Indian Med Assoc 90:265–267, 1992.
Murphy WM: Current status of urinary cytology in the evaluation of bladder neoplasms. Hum Pathol 21:886–896, 1990.
Nielsen KT, Lund L, MommsenS and OlesenS: How do we follow patients with Ta grade I-111 bladder tumors in Denmark? Scand J Urol Nephrol Suppl 172:27–31. 1995.
Pu YS, Tsai TC, Hsieh TS, et al: Role of urinary cytology and urinary deoxyribonucleic acid flow cytometry in the diagnosis of bladder cancer. J Formos Med Assoc 93:216–221, 1994.
Sehoonees R, Gamarra M, MooreR and MurphyG: The diagnostic value of urinary cytology in patients with bladder carcinoma. J Urol 106:693–696, 1971.
Shenoy UA, Colby FV and Schumann GB: Reliability of urinary cytodiagnosis in urothelial neoplasms. Cancer 56:2041–2045, 1985.
Förzsök F, KoórS and Erényi Á: Exfoliative cytological examination of the urinary tract by membrane filter technic (in Hungarian). Orv. Hetil. 147:1807–1812, 1986.
Wiener HG, Vooijs GPand vant Hof-GrootenboerB: Accuracy of urinary cytology in the diagnosis of primary and recurrent bladder cancer. Acta Cytol 37:163–169, 1993.
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Kiss, F., Salamon, F. & Sahegyi, J.R. Changing pattern of bladder cancer cytology (Haynal imre university experience). Pathol. Oncol. Res. 3, 47–50 (1997). https://doi.org/10.1007/BF02893353
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DOI: https://doi.org/10.1007/BF02893353