Abstract
A trace element preparation (Béres Drops Plus, BDP) produced immunomodulatory effects in previous in vitro and in vivo experiments. Here, C57B1/6 inbred mice were transplanted with either Lewis lung tumor or with B16 melanoma. BDP was given intraperitoneally a. before transplantation; b. after transplantation or c. after the removal of the primary tumor. As a result, BDP pretreatment could slow down the tumor progression by decreasing the number and the volume of metastases as well as the proportion of mice with metastases without influencing the growth of the primary tumors. Furthermore, BDP treatment improved the immunological activity of the tumor-bearing host, too. These preliminary data suggest that the parenteral administration of the practically non-toxic BDP could help to control tumor progression in experimental models.
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Abbreviations
- BDP:
-
Béres Drops Plus®
- 3LL:
-
Lewis lung tumor
- MM:
-
B16 melanoma
- AFC:
-
antibody forming cells
- LGL:
-
large granular lymphocytes
- RES:
-
reticuloendothelial system
- TSF:
-
thymic serum factor
- NK cells:
-
natural killer cells
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Grinevich, J.A., BÉres, J. & Bendyug, G.D. A trace element preparation increases antitumor activity in mice. Pathol. Oncol. Res. 3, 34–37 (1997). https://doi.org/10.1007/BF02893350
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DOI: https://doi.org/10.1007/BF02893350