Abstract
It has been suggested that antioxidant systems are impaired in pregnancy induced hypertension and hence patients are exposed to oxidative stress. In order to investigate the relationship between lipid peroxidation and certain antioxidant parameters in blood of pregnancy induced hypertension (PIH) cases, 25 normotensive and 23 PIH samples were studied. In the present study, thiobarbituric acid reactive substances showed a tendency to increase, however the increase remained statistically insignificant. Plasma ascorbic acid level remained unaltered and Vitamin E showed a tendency to increase in the study group. The findings implicate oxidative stress in the disease and cite the biochemical rationale for clinical trials of antioxidants to prevent and treat pregnancy induced hypertension.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Reference
Tsukatani, E. (1983). Etiology of EPH-gestosis from the view point of dynamics of vasoactive prostanoids. Lipid peroxides and vitamin E. Acta. Obstet. Gynaecol. Jpn. 35: 713–720.
Pober, J.S., Cotran, R.s. (1990), Cytokines and endothelial cell biology. Physiol. Rev. 70, 427–451.
Hubel, CA., Lyall, F., Weissfeld, L., Gandley, R.E., Roberts, JM, (1998), Small low density lipoproteins and vascular cell adhesion molecule are increased in association with hyperlipidemia in pre-eclampsia. Metabolism. 47, 1281–1288.
Rodgers, G.M, Taylor, R.N., Roberts, JM (1988), Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells. Am. J Obstet. Gynecol. 159, 908–914.
Hubel CA., Roberts, JM, Taylor, R.N., Musci, T.J., McLaughlin, M.K. (1999), Lipid peroxidation in pregnancy: New perspectives on preeclampsia. Am. J Obstet. Gynecol. 61, 1025–1034.
Burton, G. W (1994), Vitamin E: Molecular and biological junction. Proc. Nutr. Soc. 53, 251–262.
Jacob, R.A., Keley, D.S., Painetto, F.S.. (1991), Immunocompetence and oxidant defense during ascorbate depletion of healthy men. Am. J Clin. Nutr. 53, 194–200.
Tietz, N.W (1986), Methods of determination of ascorbic acid. In: Text book of Clinical biochemistry, Edited by N.W Tietz, WB. Saunders company, Philedelphia London, Toronto 960–962.
Bieri, J.G, Teets, L, Belavady, B., Andrews, E.L (1964), Serum Vitamin E levels in a normal adult population in Washington D.C Area. Proc. Soc. Exptl. Biol. Med. 117, 131–133.
Stocks, J, Dormandy, T.L (1971), The autooxidation of human red cell lipids induced by H202. Br. J. Hematol. 20, 95–111
Mikhail, MS, Anyaegbunam, A., Garfinkel,D., Palan, D., Basu, J, Romerey, SL (1994), Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, a-tocopherol and J-carotene in women with preeclampsia. Am. J Obstet. Gynecol. 171, 150–157.
Regan, CL, Levine, R.J., Baird, D.D., Ewell, M.G., Martz, KL, Sibai, B.M, Rokach, J, Lawson, JA., Fitazgerald, G.A. (2001), No evidence for lipidperoxidation in severe preeclampsia. Am. J. Obstet. Gynecol. 185(3), 572–578.
Schiff, E., Friedman, SA., Stampftr, M, Kao, L, Barret, P.H, Sibai, B.M (1996), Dietary consumption and plasma concentration of Vitamin E in pregnancies complicated by preeclampsia. Am. J Obstet. Gynecol. 175, 1024–1028
Wang, Y, Walsh, SW, Zhang, J, Jingdge, G. (1991), Maternal levels of prostacyclin, thromboxane, vitamin E and lipid peroxides throughout normal pregnancy, Am. J Obstet. Gynecol. 165, 1690–1694.
Traber, MG. (1994), Determinants of plasma Vitamin E concentrations. Free. Radic. Biol Med. 16; 229–239. 0
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rao, G.M., Sumita, P., Roshni, M. et al. Plasma antioxidant vitamins and lipid peroxidation products in pregnancy induced hypertension. Indian J Clin Biochem 20, 198–200 (2005). https://doi.org/10.1007/BF02893070
Issue Date:
DOI: https://doi.org/10.1007/BF02893070