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Usefulness of serum CA 15.3 and histopathological prognostic indices in breast cancer

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Abstract

Prognostic factors influence the modality and course of therapy in breast cancer. These include both histopathological and biochemical variables. This study was aimed to find out if any correlation exists between the biochemical tumor marker-serum CA 15.3, and the lymph node staging of Nottingham’s Prognostic Index (NPI). It was observed that serum CA 15.3 showed a statistically significant correlation with lymph node staging of NPI. Therefore it is concluded that CA 15.3 can be utilized as a useful prognostic marker, particularly in cases where histopathological variables such as tumor size and grade have been altered by pre-operative chemotherapy.

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References

  1. Chopra Rakesh (2001) Breast Cancer—The Indian scene. Journal of Clinical Oncology. 19(18 supplement), 106s-111s

    Google Scholar 

  2. Denley H., Pinder S. E., Elston, C. W., Lee A. H. S., and Ellis I. O. (2001) Preoperative assessment of prognostic factors in breast cancer. Journal of Clinical Pathology. 54, 20–24

    Article  PubMed  CAS  Google Scholar 

  3. Blamey R. W., Davies C. J., Elston C. W., Johnson Jane, Haybittle J. L., and Maynard P. V. (1979) Prognostic factors in breast cancer—the formation of a prognostic index. Clinical Oncology. 5, 227–236

    PubMed  CAS  Google Scholar 

  4. Miller W. R., Ellis I. O., Sainsbury J. R. C. and Dixon J. M. (1994) ABC of breast diseases— prognostic factors. British Medical Journal. 309, 1573–1576

    PubMed  CAS  Google Scholar 

  5. Haybittle J. L., Blamey R. W., Elston C. W., Johnson J., Doyle P. J., Campbell F. C., Nicholson R. I., and Griffiths K. (1982) A prognostic index in primary breast cancer. British Journal of Cancer. 45, 361–366.

    PubMed  CAS  Google Scholar 

  6. Galea M. H., Blamey R. W., Elston C. E., and Ellis I. O. (1992) The Nottingham’s prognostic index in primary breast cancer. Breast Cancer Research Treatment. 22, 207–219

    Article  CAS  Google Scholar 

  7. D’Eredita G., Giardina C., Martellotta M., Natale T., and Ferrarese F. (2001) Prognostic factors in breast cancer: the predictive value of the Nottingham Prognostic Index in patients with a long-term follow-up that were treated in a single institution. European Journal of Cancer. 37, 591–596

    Article  PubMed  CAS  Google Scholar 

  8. Chollet P., Amat S., Belem Bavogo E., Cure H., De Latour M., Dauplat J., Le Bouedec G., Mouret-Reynier M-A., Ferriere J-P, and Penault-Llorca F. (2003) Is Nottingham Prognostic Index useful after induction chemotherapy in operable breast cancer?. British Journal of Cancer. 89, 1185–1191

    Article  PubMed  CAS  Google Scholar 

  9. Duffy M. J. (2001) Biochemical markers in breast cancer: Which ones are clinically useful?. Clinical Biochemistry. 34, 347–352

    Article  PubMed  CAS  Google Scholar 

  10. Duffy M. J., Catherine D., Rachel K., Arnold D. K. Hill, Enda M., John Crown, and Niall O’Higgins (2004) High preoperative CA 15.3 concentrations predict adverse outcome in node-negative and node-positive breast cancer: Study of 600 patients with histologically confirmed breast cancer. Clinical Chemistry. 50(3), 559–563.

    Article  PubMed  CAS  Google Scholar 

  11. Fisher B., Bryant J., Wolmark N., Mamounis E., Brown A., Fisher E. R., Wickerham D. L., Begovic M., Decillis A., Robidoux A., Margolese R. G., Cruz Jr A. B., Hoehn J. L., Lees A. W., Dimitrov N. V., Bear H. D. (1998) Effect of pre-operative chemotherapy on the outcome of women with operable breast cancer. Journal of Clinical Oncology. 16, 2672–2685

    PubMed  CAS  Google Scholar 

  12. Giai M., Riccardo, Roagna, Riccardo Ponzone, Nicoletta, Biglia, Luca Sgro, Marco Perona, and Piero Sismondi. (1996) TPS and CA 15.3 serum values as a guide for treating and monitoring breast cancer patients. Anti-cancer Research. 16, 875–882

    CAS  Google Scholar 

  13. Bon G. S., Von Mensdorff-Pouilly S., Kenemans P., Van Kamp G. J., Verstraeten R. A., Hilgers J. (1997). Clinical and technical evaluation of ACS BR serum assay of MUC 1 gene-derived glycoprotein in breast cancer and comparison with CA 15.3 assay. Clinical Chemistry. 47, 585–593.

    Google Scholar 

  14. Rosner B. (2000). Fundamentals of biostatistics. Duxbury Thompson Learning. 5th edition. 792 pages.

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Authors and Affiliations

  1. Department of Pathology, St. John’s Medical College, Bangalore

    Purnima M. Makhija & Sheila Uthappa

  2. Department of Biochemistry and Biophysics, St. John’s Medical College, Sarjapur Road, John Nagar, 560034, Bangalore

    Nalini R. & Wilma Delphine Silvia C. R.

Authors
  1. Nalini R.
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  2. Wilma Delphine Silvia C. R.
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  3. Purnima M. Makhija
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  4. Sheila Uthappa
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Nalini, R., Wilma Delphine Silvia, C.R., Makhija, P.M. et al. Usefulness of serum CA 15.3 and histopathological prognostic indices in breast cancer. Indian J Clin Biochem 20, 165–168 (2005). https://doi.org/10.1007/BF02893065

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