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Oxidant status and lipid profile in vegetarians and fish eaters

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Abstract

Habitual consumption of moderate amounts of fish is associated with reduced mortality from coronary heart disease. However the beneficial effects of fish enriched diet seem contradictory, due to the susceptibility of the PUFAs in them to oxidation. It is also acclaimed that vegetarians in general, have a lower serum total cholesterol and LDL-cholesterol and a better antioxidant status. This contradiction was the basis for the study, where the validity of the above finding was tested in a general population consuming a vegetarian or predominantly fish diet as a regular dietary habit. The oxidant status and the lipid profile of 23 vegetarians and 22 fish eaters was studied by estimating the plasma lipid peroxides measured as malondialdehyde (MDA) and the lipid parameters viz. Total Cholesterol (TC), HDL-Cholesterol (HDL-C) and triglycerides (TG). Statistical analysis was carried out to compare the MDA values and the lipemic status between the two groups. MDA was also correlated with the various lipid indices among the study groups. None of the compared and correlated values was statistically significant, although certain altered trends were seen. From this study, it may be concluded that oxidant status and lipid profile does not vary significantly in the two groups, suggesting that neither a vegetarian diet nor a fish diet has a definite benefit over the other.

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References

  1. Kromhout D, Bosschieter EB, Colanders C. (1985) The inverse relation between fish consumption and 20 year mortality from coronary heart disease. N Engl J Med. 312, 1205–9.

    PubMed  CAS  Google Scholar 

  2. Norell SE, Ahlbom A, Feychting M, Pedersen NL. (1986) Fish consumption and mortality from coronary heart disease. Br Med J. 426.

  3. Shekelle RB, Misell L, Oglesby P. (1985) Fish consumption and mortality from cardiovascular disease. N Engl J Med. 313, 820.

    Google Scholar 

  4. Bang H O, Dyerberg J. (1972) Plasma lipids and lipoproteins in Greenland West Coast Eskimos. Acta Medica Scandinavia. 192, 85–94.

    CAS  Google Scholar 

  5. Bang H O, Dyerberg J, Hjoome N. (1976) The composition of food consumed by Greenland Eskimos. Acta Medica Scandinavia. 200, 69–73.

    CAS  Google Scholar 

  6. Sacks FM, Wood PG, Koss EH. (1984) Stability of blood pressure in vegetarians receiving dietary protein supplement. Hypertension. 6, 199–201.

    PubMed  CAS  Google Scholar 

  7. Kris-Etherton PM, Krummel D, Russell ME. (1987) The effect of diet on plasma lipids, lipoprotein and coronary heart disease. J Am Diet Assoc. 88, 1373–400.

    Google Scholar 

  8. Pan WH, Chin C, Shew C, Lee M. (1993) Hemostatic factors and blood lipids in young Buddhist vegetarians and omnivores. Am J Clin Nutr. 58, 354–9.

    PubMed  CAS  Google Scholar 

  9. Liu S, Manson JE, Lee M, Cole SR, Hennekens CH, Willette WC, Buring JE.(2000) Fruit and vegetable intake and risk of Cardiovascular disease: the women’s health study. Am J Clin Nutr. 72, 922–8.

    PubMed  CAS  Google Scholar 

  10. Poornima K, Cariappa M, Asha K, Kedilaya HP, Nandini M (2003) Oxidant and antioxidant status in vegetarians and fish eaters. Ind. J. Clin. Biochem. 18 (2), 197–205.

    Article  Google Scholar 

  11. Bucala R. (1996) Lipid and lipoprotein oxidation : basic mechanisms and unresolved questions in view. Redox Report. 291–307.

  12. Jialal I, Devaraj S. (1996) Low density lipoprotein oxidation, antioxidants and atherosclerosis: a clinical biochemistry perspective. Clin Chem. 42, 498–506.

    PubMed  CAS  Google Scholar 

  13. Ohara Y, Peterson TE, Harrison DG. (1993) Hypercholesterolemia increases endothelial superoxide anion production. J clin Invest. 91, 2546–51.

    Article  PubMed  CAS  Google Scholar 

  14. Esterbauer H, Cheeseman KH. (1990) Determination of aldehydic lipid perodixation products: Malondialdehyde and 4-hydroxynonenal. Methods in enzymology. Academic Press. 186, 407–21.

    Article  PubMed  CAS  Google Scholar 

  15. Wasowicz W, Neve J, Peretez A. (1993) Optimised steps in fluorometric determination of thiobarbituric acid reactive substances in serum: Importance of extraction pH and influence of sample preservation and storage. Clin Chem. 39, 2522–26.

    PubMed  CAS  Google Scholar 

  16. Allain CC, Poon LS, Chan CSG. (1974) Enzymatic determination of total serum cholesterol. Clin Chem. 20, 470–75.

    PubMed  CAS  Google Scholar 

  17. Burnstein, Scholnick M. (1973) Lipoprotein MR, Lipoprotein-Metal interactions. Adv Lipid Res. 11, 67–108.

    Google Scholar 

  18. Werner M, Gabrielson DG, Eastman G. (1981) Ultra micro determination of serum triglycerides by bioluminiscent assay. Clin Chem. 27, 268–71.

    PubMed  CAS  Google Scholar 

  19. Bucolo G, David H. (1973) Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 19, 476–82.

    PubMed  CAS  Google Scholar 

  20. Friedwald WT, Levy RI, Fredrickson DS. (1972) Estimation of concentration of low-density lipoprotein cholesterol without the use of the preparative ultracentrifuge. Clin Chem. 18, 499.

    Google Scholar 

  21. Frost PH, Havel RJ. (1998) Rationale for use of non-high density lipoprotein rather than low density lipoprotein cholesterol as a tool for lipoprotein cholesterol screening and assessment of risk and therapy. Am J Cardiol. 81, 26B-31B.

    Article  PubMed  CAS  Google Scholar 

  22. Higdon JV, Lice J, Morrow JD, Ames BN, Wander RC. (2000) Supplementation of postmenopausal women with fish oil rich in EPA and DHA is not associated with greaterin vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F2-isoprostanes. Am J Clin Nutr. 72, 714–22.

    PubMed  CAS  Google Scholar 

  23. Bhattacharya J, Srivastava DK. (1993) Serum malondialdehyde in relation to lipidemic status and atherogenic index. Indian Journal of clinical biochemistry. 8, 12–15.

    Article  Google Scholar 

  24. Meydani M, Evans WJ, Handelman G. (1993) Protective effect of vitamin E on exercise induced oxidative damage in young and older adults. Am J Physiol. 264, 992–8.

    Google Scholar 

  25. Piche LA, Draper HH, Cole PD. (1988) Malondialdehyde excretion by subject consuming cod liver oil versus a concentrate of n-3 fatty acids. Lipids. 23, 370–1.

    Article  PubMed  CAS  Google Scholar 

  26. Mouri K, Ikesu H, Esaka T, Igarashi Q. (1984) The influence of marine oil intake upon levels of lipids, alpha tocopherol and lipid peroxidation in serum and liver of rats. J Nutr Sci Vitaminol. 30, 307–18.

    PubMed  CAS  Google Scholar 

  27. Skuladottir GV, Du SH, Brodie AE, Reed DJ. Wander RC. (1994) Effects of dietary oils and methyl ethyl ketone peroxide onin vivo lipid peroxidation and antioxidants in rat heart and liver. Lipids. 29, 351–7.

    Article  PubMed  CAS  Google Scholar 

  28. Saito M, Kubo K, Ikegami S. (1996) An assessment of DHA intake with special reference to lipid metabolism in rats. J Nutr Sci Vitaminol. 42, 195–207.

    PubMed  CAS  Google Scholar 

  29. Austin MA. (1991) Plasma triglycerides and coronary heart disease. Arterioscler Thromb. 11, 2–14.

    PubMed  CAS  Google Scholar 

  30. Hokanson JE, Austin MA. (1996) Plasma triglyceride is a risk factor for cardiovascular disease independent of high density lipoprotein cholesterol: a meta analysis of population based prospective studies. J Cardiovasc Risk. 3, 213–19.

    Article  PubMed  CAS  Google Scholar 

  31. Herold PM, Kinsella JE. (1986) Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trials. Am J Clin Nutr. 43, 566–98.

    PubMed  CAS  Google Scholar 

  32. Tavia G, William P, Castelli MD, Marthana CH, William BK, Thomas RD (1977). High density lipoprotein as a protective factor against coronary heart disease the Framingham study. The American Journal of Medicine. 62, 707–713.

    Article  Google Scholar 

  33. Gofman JW, Young W, Tandy R. (1996) Ischaemic heart disease atherosclerosis and longevity. Circulation. 34, 679.

    Google Scholar 

  34. Goldbourt U, Medali JH. (1997) Cholesterol in alpha lipoprotein and clinical myocardial infarction. In: Gordon T, Castaelli WP, Hjotland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. Am J Med. 62, 707–13.

    Google Scholar 

  35. Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs Jr DR, Bangdiwala S, Tyroller HA. (1989) High density lipoprotein cholesterol and cardiovascular disease. Circulation. 9, 9–15.

    Google Scholar 

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Authors and Affiliations

  1. Dept. of Biochemistry, Center For Basic Sciences, Kasturba Medical College, Bejai, 575 004, Mangalore

    M. Cariappa, K. Poornima & M. Nandini

  2. Dept. of Community Medicine, Kasturba Medical College, 575 001, Mangalore

    K. Asha

  3. Dept. of Biochemistry, A.J. Institute of Medical Sciences, Kuntikan, 575 004, Mangalore, Karnataka, India

    H. P. Kedilaya

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  2. K. Poornima
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  5. H. P. Kedilaya
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Cariappa, M., Poornima, K., Nandini, M. et al. Oxidant status and lipid profile in vegetarians and fish eaters. Indian J Clin Biochem 20, 103–108 (2005). https://doi.org/10.1007/BF02893052

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