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Altered pattern of lipids in plasma and erythrocyte membranes of rheumatoid arthritis patients

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Abstract

The present study has investigated the levels of lipids, lipoprotein cholesterol (HDL and LDL cholesterol), thiobarbituric acid reactive substances (TBARS) and vitamin E in plasma and erythrocyte membranes of twenty two clinically diagnosed adult rheumatoid arthritis patients and an equal number of age matched healthy subjects. The levels of lipids and lipoprotein cholesterol were markedly reduced in patients with rheumatoid arthritis as compared to healthy subjects. The altered lipid pattern may be related to decreased lipoprotein cholesterol, fatty acids and impairment in antioxidant defence mechanism.

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References

  1. Deborah, P.M. (2002) Epidemiology of rheumatoid arthritis: determinants of onset, persistence and out come.Clin Rheum. 111, 172–7.

    Google Scholar 

  2. Gabriel, S.E. (2001) The epidemiology of rheumatoid arthritis.Rheum Dis Clin North Am. 27, 269–281.

    Article  PubMed  CAS  Google Scholar 

  3. Shichikawa, K., Inoue, K., Hirota, S., Maeda, A., Ota, H., Kilmura, M., Ushiyama, T. and Tsujimoto, M. (1999) Changes in the incidence and prevalence of rheumatoid arthritis.Ann Rheum Dis. 58, 751–756.

    Article  PubMed  CAS  Google Scholar 

  4. Manoharan, S., Ramachandran, C.R. and Nagini, S. (1995) The altered lipid profile in oral cancer patients is related to life style.Med Sci Res. 23, 493–95.

    Google Scholar 

  5. Kashyap, M.L., Prete, P.E. and Gurakar-Osborme, A. (1995) Synovial fluid lipids and apolipoproteins: a contemporary perspective.Biorheology. 32, 1–16.

    PubMed  Google Scholar 

  6. Magaro, M., Altomonte, L., Zoli, A., Mirone, L. and Ruffini, M.P. (1991) Serum lipid pattern and apolipoproteins in active rheumatoid arthritis.Z Rheumatol. 50, 168–70.

    PubMed  CAS  Google Scholar 

  7. Salazar, A., Pinto, X. and Mana, J. (2001) Serum amyloid A and high density lipoprotein cholesterol: serum markers of inflammation in sarcoidosis and other systemic disorders.Eur J Clin Invest. 31, 1070–7.

    Article  PubMed  CAS  Google Scholar 

  8. Lazarevic, M.B., Skosey, J.L., Vitic, J., Mladenovic, V., Myones, B.L., Popovic, J. and Swedler, W.I. (1993) Cholesterol crystals in synovial and bursal fluid.Semin Arthritis Rheum. 23, 99–103.

    Article  PubMed  CAS  Google Scholar 

  9. Dodge, J.F., Mitchell, G. and Hanahan, D.J. (1968) The preparation and chemical characterization of haemoglobin free ghosts of human red blood cells.Arch Biochem Biophys. 110, 119–130.

    Google Scholar 

  10. Quist E.H. (1980) Regulation of erythrocyte membrane shape by calcium ion.Biochem Biophys Res Commun. 92, 631–637.

    Article  PubMed  CAS  Google Scholar 

  11. Parekh, A.C. and Jung, D.H. (1970) Cholesterol determination with ferric acetate—uranium acetate reagent and sulphuric acid ferrous sulphate reagents.Anal Chem. 42, 1423–1427.

    Article  CAS  Google Scholar 

  12. Zilversmit, D.B. and Davies, A.K. (1950) Microdetermination of plasma phospholipids by trichloroacetic acid precipitation.J Lab Clin Med. 35, 155–160.

    PubMed  CAS  Google Scholar 

  13. Gidez, T.I., Miller, G.J., Burstein, M., Slage, S. and Eder, H.A. (1982) Separation and quantitation of subclasses of human plasma high density lipoproteins by simple precipitation procedure.J Lip Res. 23, 1206–1223.

    CAS  Google Scholar 

  14. Foster, C.S. and Dunn, O. (1973) Stable reagent for determination of serum triglycerides by a colorimetric Hantzsch condensation method.Clin Chem. 19, 338–340.

    PubMed  CAS  Google Scholar 

  15. Falholf, K., Falholf, W. and Lund, B. (1973) An easy colorimetric method for routine determination of free fatty acid in plasma.Clin Chim Acta. 46, 105–111.

    Article  Google Scholar 

  16. Prete, P.E. and Gurakar-Osbome, A. (1997) The contribution of synovial fluid lipoproteins to the chronic synovitis of rheumatoid arthritis.Prostaglandins. 54, 689–98.

    Article  PubMed  CAS  Google Scholar 

  17. Lorber, M., Aviram, M., Linn, S., Scharf, Y. and Brook, J.G. (1985) Hypocholesterolaemia and abnormal high density lipoprotein in rheumatoid arthritis.Br J Rheumatol. 24, 250–5.

    Article  PubMed  CAS  Google Scholar 

  18. Honkanen, V.E., Pelkonen, P. and Konttinen, Y.T., Mussalo-Rauhamaa, H., Lehto, J. and Westermarck, T. (1990) Serum cholesterol and vitamins A and E in juvenile chronic arthritis.Clin Exp Rheumatol. 8, 187–91.

    PubMed  CAS  Google Scholar 

  19. Taysi S, Polat F, Gul M, Sari RA, Bakan E. Lipid peroxidation, some extracellular antioxidants, and antioxidants enzymes in serum of patients with rheumatoid arthritis.Rheumatol Int 2002; 21: 200–4.

    Article  PubMed  CAS  Google Scholar 

  20. Scherak O, Kolarz G. Vitamin E and rheumatoid arthritis.Arthrit Rheum 1991; 34: 1205–6.

    Article  CAS  Google Scholar 

  21. Gorska, A., Nawrocki, A., Urban, M. and Florys, B. (2000) Composition of phospholipid fatty acids in erythrocyte membranes of children with chronic juvenile arthritis: clinical and biochemical correlations.Med Sci Monit. 6, 30–9.

    PubMed  CAS  Google Scholar 

  22. Masoom-Yasinzai, M. (1996) Altered fatty acid, cholesterol and Na+/K+ ATPase activity in erythrocyte membrane of rheumatcid arthritis patients.Z Naturforsch. 51, 401–3.

    CAS  Google Scholar 

  23. Van Deenen, L.L.M. and De Gier, J. (1964) In: chemical composition and metabolism of lipids in red cells of various animal species. Bioshop, C. and Surgenor, D.M. (eds.), Academic Press, New York, p. 243–307.

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Science, Annamalai University, 608 002, Annamalai Nagar, Tamilnadu, India

    D. Vijayakumar, K. Suresh & S. Manoharan

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  1. D. Vijayakumar
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  2. K. Suresh
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  3. S. Manoharan
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Correspondence to S. Manoharan.

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Vijayakumar, D., Suresh, K. & Manoharan, S. Altered pattern of lipids in plasma and erythrocyte membranes of rheumatoid arthritis patients. Indian J Clin Biochem 20, 52–55 (2005). https://doi.org/10.1007/BF02893042

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