Skip to main content
Log in

Antioxidant status and peroxidative stress in mother and newborn —A pilot study

  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Serum antioxidant status and peroxidative stress was estimated in 30 pregnant women, their newborn infants and 25 non-pregnant women. Serum Ascorbic acid, α-tocopherol, retinol & β-carotene levels were found to be significantly reduced and peroxidative stress was significantly higher in mothers as compared to matched non-pregnant women. Newborn had significantly higher levels of ascorbic acid as compared to their mother but had significantly lower levels of lipid soluble vitamins. The peroxidative stress in newborn was found to be significantly less as compared to their mothers. A positive correlation of ascorbic acid and α-tocopherol levels between mother and newborn reflects that their status in mother does influence the newborn status.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Bibliography

  1. Quanungo, S., Mukherjea, M. (2000) Ontogenic profile of some antioxidants and lipid per-oxidation in human placental and fetal tissues. Mol. Cell. Biochem. Dec, 215, (1–2): 11–9.

    Article  Google Scholar 

  2. Clapp, J.F. (1988) Maternal physiological adaptation during early human pregnancy. Am.J. Obstet Gynaecol.

  3. Pernoll, M.L., Metcalfe, J., Kovacl, P.A. et al (1975) ventilation during rest and exercise in in pregnancy & Post partum Respir, Physiol 25, 295.

    CAS  Google Scholar 

  4. Alaily, A.B. and Carral, K.B. (1978) Pulmonary ventilation in pregnancy. Br. J. Obstet Gynaecol 85; 518.

    PubMed  CAS  Google Scholar 

  5. Lachilli, B., Hininger, I., Faure, H., Arnaud, J., Richard, M.J., Favier, A., Roussel, A.M. (2001) Increased lipid per-oxidation in pregnant women after Iron and vitamin C supplementation. Boil. Trace. Elem. Res. Nov, 83(2): 103–10.

    Article  Google Scholar 

  6. Natelson, S. (1971) Techniques of clinical chemistry Charles C Thomas Springfield, Illinois USA: 162–65.

    Google Scholar 

  7. Barker, H. and Frand, O. (1968) In: Clinical vitaminology, methods and interpretation, Interscience publishers. Joh wiley and sons. Inc. New York. P 172.

    Google Scholar 

  8. Barry Halliwell and Susanna Chirico (1993) Lipid Per-oxidation: its mechanism, measurement and significance. Am. J. clin. Nutr. 57(1): 7, 15S–25S.

    Google Scholar 

  9. Gitto, E., Reiter, R.J., Karbownik, M., Tan, D.X., Gitto, P., Barberi, S., Barberi, I. (2002) Causes of oxidative stress in the pre and perinatal period. Biol. Neonate. 81(3) 146–57.

    Article  PubMed  CAS  Google Scholar 

  10. John, B. West. (1991) Best in Taylor’s Physiological Basis of Medical Practice, 12th ed, P.P. 894

  11. Alberti-Fidanza, A., Di Renzo, G.C., Burini, G. Antonelli, G., Perriello, G. (2002) Diet during pregnancy and total antioxidant capacity in maternal and umbilical cord blood. J. Matern. Fetal. Neonatal. Med. Jul, 12(1) 59–63.

    Article  CAS  Google Scholar 

  12. Soni, N.D., Sharma, Praveen., Kiran, C., Pramod, J., Kothari, L.K. (1989) Leucocyte and Serum Ascrobic acid levels in mothers and their newborn in semi arid western India. Indian. J. Physiol. Pharmac. 33, (4). 239–242.

    CAS  Google Scholar 

  13. Pritchard, J.A. (1965) Changes in the blood volume during pregnancy and delivery. Anesthesiology. 26, 393–9.

    Article  PubMed  CAS  Google Scholar 

  14. Khattab, A.K. et al (1970) Foetal maternal ascorbic acid gradient in normal Egyptian subjects. J. Trop. Pediatr. 17, 16. 112–5.

    Google Scholar 

  15. Ibeziako, P.A., Ette, S.I. (1981) Plasma ascorbic acid levels in Nigerian mothers and newborn. J. Trop. Pediatr. 27. 263–6.

    PubMed  CAS  Google Scholar 

  16. Bohles, H. (1997) Antioxidative vitamins in prematurely and maturely born infants. Int. J. Vitam. Nutr. Res. 67(5). 321–8.

    PubMed  CAS  Google Scholar 

  17. Yehum, K.J., Ferland, G., Party, J., Russel, R.M. (1998) Relationship of plasma carotenoids, retinol and tocopherols in mothers and newborn infants. J. Am. Coll. Nutr. Oct, 17(5). 442–7

    Google Scholar 

  18. Baydas, G., Karatas, F., Gursu, M.F., Bozkurt, H.A., Ilhar, N., Yasar, A., Canatan, H. (2002) Antioxidant vitamin levels in term and preterm infants and their relation to maternal vitamin status. Arch. Med. Res. May–Jun, 33(3). 276–80.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Praveen Sharma.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Upadhyaya, C., Mishra, S., Singh, P.P. et al. Antioxidant status and peroxidative stress in mother and newborn —A pilot study. Indian J Clin Biochem 20, 30–34 (2005). https://doi.org/10.1007/BF02893038

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02893038

Key Words

Navigation