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Ultrastructure of adult T-cell leukemia/lymphoma

Virchows Archiv B volume 38, Article number: 189 (1981) Cite this article

Summary

Eighteen cases of adult T-cell leukemia/lymphoma (ATLL) in Japan were analyzed by electron microscopy and compared with 5 cases of B-lymphoma and well-established groups of T-lymphomas (4 cases of T-lymphoblastic lymphoma and 2 cases of Sézary syndrome). Five hundred cells in each case, categorized ultrastructurally as to the cellular size and nuclear shape, showed an essentially pleomorphic cellular distribution in ATLL in remarkable contrast with the monomorphism of B-“histiocytic”, B-well-differentiated lymphocytic, and T-lymphoblastic lymphomas. Some B-lymphomas and Sézary syndrome also showed pleomorphism. Cases of ATLL were classified according to the predominant cells and degree of nuclear irregularity, which delineated a spectrum of node-based, peripheral T-cell neoplasms probably encompassing T-immunoblastic sarcoma, T-zone lymphoma, as well as multilobated T-cell lymphoma. The characteristic fine structure of ATLL, in comparison with that of B-lymphomas, included slight to marked nuclear irregularity with convoluted-shape predominance, a speckled chromatin pattern of the large cells, prominent lysosomes, and glycogen accumulation in addition to the difference in cellular distribution. Although T-lymphoblastic lymphoma and Sézary syndrome shared some of these features, the ultrastructural differentiation of ATLL from them seems to be possible.

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Affiliations

  1. Dept. of Pathology, Fukuoka University School of Medicine, Nanakuma 34, Nishi-ku, 814-01, Fukuoka, Japan

    Tadaaki Eimoto M.D., Tetsuji Mitsui & Masahiro Kikuchi

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  1. Tadaaki Eimoto M.D.
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  2. Tetsuji Mitsui
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  3. Masahiro Kikuchi
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Eimoto, T., Mitsui, T. & Kikuchi, M. Ultrastructure of adult T-cell leukemia/lymphoma. Virchows Archiv B Cell Pathol 38, 189 (1981). https://doi.org/10.1007/BF02892814

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  • DOI: https://doi.org/10.1007/BF02892814

Key words

  • Lymphoma
  • Ultrastructure
  • T-lymphocyte
  • B-lymphocyte