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Serum lysozyme in mice subjected to combined immunosuppression with 6-mercaptopurine and hydrocortisone

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Abstract

Simultaneous peroral administration of 6-mercaptopurine (80 mg/kg per day) and subcutaneous injection of hydrocortisone (1 mg/mouse per day) for ten days results in increased lethality and more pronounced decrease in total peripheral leukocyte count and serum lysozyme levels as compared with mice receiving each drug separately. The possible mechanism of this effect is discussed.

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Authors and Affiliations

  1. Department of Medical Microbiology, Medical School, Charles University, 500 38, Hradec Králové

    J. Prixová

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  1. J. Prixová
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Prixová, J. Serum lysozyme in mice subjected to combined immunosuppression with 6-mercaptopurine and hydrocortisone. Folia Microbiol 20, 509–512 (1975). https://doi.org/10.1007/BF02891711

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  • DOI: https://doi.org/10.1007/BF02891711

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