Summary
Numerous blebs were observed in contact with smooth muscle cells (SMC) by light microscopy in the myometrium of the rat uterus after parturition. Electron-microscopically the cell surface of SMC showed bulbous protrusions, which often lacked a basement membrane and were less electron-dense than the surrounding cytoplasm or sometimes nearly electron-lucent. Many bulbous protrusions were separated from SMC and became the isolated structures which we called cytoplasmic blebs. These bulbous protrusions and cytoplasmic blebs were often found to be phagocytosed by fibroblast-like cells and macrophages. A series of these tissue changes in the uterine myometrium after delivery, possibly due to hypoxic conditions, contribute to a rapid involution of SMC which have enlarged during pregnancy.
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References
Afting E-G, Elce JS (1978) DNA in the rat uterus myometrium during pregnancy and postpartum involution. Measurement of DNA in small pieces of mammalian tissue. Anal Biochem 86:90–99
Dessouky DA (1968) Electron microscopic studies of the myometrium of the guinea pig. The smooth muscle cell of the myometrium before and during pregnancy. Am J Obst Gynec 100:30–41
Joris I, Majno G (1977) Cell to cell herniae in the arterial wall. I. The pathogenesis of vacuoles in the normal media. Am J Pathol 87:375–398
Kameya Y (1963) Electron microscopic study of the uterine smooth muscle of a pregnant rabbit. Comparison between the pregnant and non-pregnant uterine horns of the bicornuate uterus of a rabbit. J Electronmicrosc 12:100–102
Mäher JA, Arbor A (1959) Morphologic and histochemical changes in postpartum uterine blood vessels. AMA Arch Pathol 67:175–180
Maibenco HG (1960) Connetive tissue changes in postpartum uterine involution in the albino rat. Anat Rec 136:59–71
Montfort I, Pérez-Tamayo R (1961) Studies on uterine collagen during pregnancy and puerperium. Lab Invest 10:1240–1258
Okamura H, Koshiba H, Yoshida Y, Nishimura T (1976) An ultrastructural study of collagen degradation in human involuting uterus. Acta Obst Gynaec Jpn 23:179–184
Thoenes W 1964) Mikromorphologie des Nephron nach temporärer Ischämie. In: Bargmann W, Doerr W (ed) Zwanglose Abhandlung aus dem Gebiet der normalen und pathologischen Anatomie. Thieme Verlag, Stuttgart
Wagner R, Gabbert H, Höhn P (1979) The mechanism of epithelial shedding after ischemic damage to the small intestinal mucosa. A light and electron microscopic investigation. Virchows Arch [Cell Pathol] 30:25–31
Warning A, Thoenes W (1972) Morphologische Untersuchungen zur Okklusion und Wiedereröffnung proximaler Nierentubuli bei kurzfristiger Ischämie. Virchows Arch [Cell Pathol] 11:310–325
Yamamoto I (1961) An electron microscope study on development of uterine smooth muscle. J Electronmicrosc 10:145–160
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Inouye, S., Iyama, Ki., Araki, C. et al. Phagocytosis of cytoplasmic blebs derived from smooth muscle cells by fibroblast-like cells and macrophages in the post-partum rat uterus. Virchows Archiv B Cell Pathol 42, 235–242 (1983). https://doi.org/10.1007/BF02890386
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DOI: https://doi.org/10.1007/BF02890386