Summary
Groups of mice were inoculated with strains ofToxoplasma gondii of either high or low virulence strains. The response of the lymph nodes, spleen and thymus was studied histologically and antibodies were assessed by the dye-test technique. The low-virulence strain induced changes in all three organs indicative of an immunological response, both in respect of cellular and humoral immunity. The high-virulence strain produced rapid lymphoid depletion in lymph nodes, spleen and thymus with areas of necrosis. It is suggested that the high-virulence strain has a toxic effect on the Reticulo-Endothelial system allowing unrestricted proliferation of the organism with eventual death.
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Henry, L., Beverley, J.K.A. The response of the mouse R-E system to infection withToxoplasma gondii . Virchows Arch. B Cell Path. 20, 55–69 (1976). https://doi.org/10.1007/BF02890326
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DOI: https://doi.org/10.1007/BF02890326