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Evolution of aurosomes in rabbit synovial membrane

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Virchows Archiv B

Summary

Intra-articular injection of sodium aurothiomalate (Myochrysine) into rabbit knee joints produced lysosomes (aurosomes) of a characteristic morphology in synovial intimal cells and subsynovial macrophages. Such lysosomes are distinct and different from other lysosomes and those seen after injection of sodium thiomalate. A study of the morphological events that occur after injection of gold salt shows that at first the aurosome contains electrondense granules but later membranous formations (myelinoid membranes) presenting as rod-like and curled structures develop. With electron probe x-ray analysis, gold, phosphorus, and traces of calcium were detected in the aurosome.

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Authors and Affiliations

  1. The Department of Pathology, University of Saskatchewan, Room A 216, Medical Building, S7N 0W8, Saskatoon, Saskatchewan, Canada

    A. F. Oryschak & F. N. Ghadially

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  1. A. F. Oryschak
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  2. F. N. Ghadially
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Oryschak, A.F., Ghadially, F.N. Evolution of aurosomes in rabbit synovial membrane. Virchows Arch. B Cell Path. 20, 29–39 (1976). https://doi.org/10.1007/BF02890324

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  • DOI: https://doi.org/10.1007/BF02890324

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