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Spatial distribution of Langerhans’ cells and T-lymphocyte subpopulations in human tympanic membrane and aural cholesteatoma

Virchows Archiv B volume 52, Article number: 143 (1986) Cite this article

Summary

Immunohistochemical analysis of human cholesteatoma matrices revealed the presence of Langerhans’ cells and T-lymphocytes. Through cell-to-cell interaction, Langerhans’ cells probably play a key role in skin-related disorders, including cholesteatomas. They probably originate from a mobile cell population of monocyte origin and migrate into and out of the body’s lining. Their custodial function is often carried out in close relation with T-lymphocytes. Monoclonal antibodies against Langerhans’ cells and T-lymphocyte membrane receptors reveal the presence of these cell populations in cholesteatoma matrices but not in the tympanic membrane. Langerhans’ cells and T-cell “traffic” through cholesteatomas are discussed in relation to the pathogenesis, natural course and recurrence of cholesteatomas. Through immunopathologic evaluation the clinical aggressiveness of a cholesteatoma may become predictable. It may even have consequences for the future handling of cholesteatomas.

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Affiliations

  1. Laboratory of Histophysiology and Exp. Pathology, University of Utrecht, The Netherlands

    C. M. van Dijk & C. E. Visser

  2. Department of Otorhinolaryngology, University Hospital, Catharijnesingel 101, 3511, GV Utrecht, The Netherlands

    J. E. Veldman

Authors
  1. C. M. van Dijk
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  2. C. E. Visser
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  3. J. E. Veldman
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Additional information

This investigation was supported by a grant from the Heinsius-Houbolt Fund, The Netherlands

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van Dijk, C.M., Visser, C.E. & Veldman, J.E. Spatial distribution of Langerhans’ cells and T-lymphocyte subpopulations in human tympanic membrane and aural cholesteatoma. Virchows Archiv B Cell Pathol 52, 143 (1986). https://doi.org/10.1007/BF02889958

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  • DOI: https://doi.org/10.1007/BF02889958

Key words

  • Tympanic membrane
  • Cholesteatoma
  • Langerhans’ cells
  • T-lymphocytes
  • Monoclonal antibodies