Summary
The phagocytic capacity of the glomerular mesangial cells in 42 rats was inhibited by the prolonged injection of PVA. Morphometric evaluation of electron microscopic sections showed that this treatment leads to an accelerated thickening of the lamina densa of the glomerular basement membrane and of the mesangial matrix (early glomerulosclerosis). This suggests that a disturbance of lysosomal degradation can lead to glomerulosclerosis, and that the possibility of mesangial dysfunction should always be considered as a possible factor in the pathogenesis of all types of diffuse glomerulosclerosis.
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References
Andrew, W., Pruett, D.: Senile changes in the kidneys of wistar institute rats. Am. J. Anat.100, 51–79 (1957)
Farquhar, M.G., Palade, G.E.: Functional evidence for the existence of a third cell type in the renal glomerulus. Phagocytosis of filtration residues by a distinctive “Third” cell. J. Cell Biol.13, 55–87 (1962)
Fresen, O., Sadony, V.: Untersuchungen des retothelialen Systems mit Isotopen. Klin. Wochenschr.45, 277–281 (1967)
Fushimi, H., Tarui, S.: β-Glycosidases and diabetic microangiopathy. I. Decreases of β-glycosidase activities in diabetic rat kidney. J. Biochem.79, 265–270 (1976)
Hall, C.E., Hall, O.: Polyvinyl alcohol: relationship of physiochemical properties to hypertension and other pathophysiological sequelae. Lab. Invest.12, 721–736 (1963)
Heck, Th., Hempel, K., Lange, H.-W., Romen, W.: Untersuchungen zum Turnover von Kollagen in der glomerulären Basalmembran von gesunden und diabetischen Ratten. Verh. Dtsch. Ges. Path.62, 386 (1978)
Jørgensen, F., Weis-Bentzon, M.: The ultrastructure of the normal human glomerulus. Thickness of glomerular basement membrane. Lab. Invest.18, 42–48 (1968)
Kimmelstiel, P.: Diabetische Glomerulosklerose. Verh. Dtsch. Ges. inn. Med.74, 95–102 (1968)
Lazarow, A., Speidel, E.: The chemical composition of the glomerular basement membrane and its relationship to the production of diabetic complications. In: Small blood vessel involvement in diabetes mellitus, M.D. Siperstein, A.R. Colwell, K. Meyer (eds.), pp. 127–150. Washington, D.C.: Amer. Inst. Biolog. Sciences 1964
Mauer, S.M., Steffes, M.W., Michael, A.F., Brown, D.M.: Studies of diabetic nephropathy in animals and man. J. Am. Diab. Ass.25, 850–857 (1976)
McNelly, N.A., Dittmer, J.E.: Glomerular basement membrane width and proteinuria in the aging hamster kidney. Exp. Geront.11, 49–55 (1975)
Pardo, V., Shapiro, A.P.: Ultrastructural glomerular lesions produced by synthetic polysaccharides. Lab. Invest.15, 617–621 (1977)
Romen, W.: Problem der Glomerulosklerose. Veröffentlichungen aus der Pathologie,102, 1–102. Stuttgart: Fischer 1976.
Spiro, R.G.: Search for a biochemical basis of diabetic microangiopathy. Diabetologia12, 1–14 (1976)
Sterzel, R.B., Mariss, P., Reale, E.: Experimentelle Veränderungen der mesangialen Klärfunktion bei Ratten. XI. Symp. der Ges. Nephrol. München, Nr. 100 (1976)
Weibel, E.R.: Stereological principles for morphometry in electron microscopic cytology. Internat. Rev. Cytol.26, 235–302 (1969)
Yagihashi, S.: Age-related changes of glomerular basement membrane in rats. Tohoku J. Exp. Med.126/I, 85 (1978)
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Romen, W., Morath, R. Diffuse glomerulosclerosis—A dysfunction of the mesangium?. Virchows Archiv B Cell Pathol 31, 205–210 (1979). https://doi.org/10.1007/BF02889937
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DOI: https://doi.org/10.1007/BF02889937