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Detection by S-100 immunolabelling of interdigitating reticulum cells in human thymomas

Virchows Archiv B volume 45, Article number: 187 (1984) Cite this article

Summary

In the light of recent findings concerning the presence of S-100 antigen in interdigitating reticulum cells (IRC’s) in the normal human thymus, we investigated the possible presence of these cells in human thymomas. By the unlabelled antibody PAP method, using an anti-S-100 antiserum, both by light and electron microscopy we were able to demonstrate immunolabelled IRC’s in the majority of spindle cell and in some round-oval cell thymomas. Keeping in mind the possible role of IRC’s in intrathymic T-cell differentiation, the present findings could be relevant in the better comprehension of this thymic neoplasm.

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Affiliations

  1. Department of Pathology, Università Cattolica, I-00168 Via Pineta Sacchetti, 644, Roma, Italy

    Libero Lauriola

  2. Department of Anatomy, Università Cattolica, I-00168 Via Pineta Sacchetti, 644, Roma, Italy

    Fabrizio Michetti, Vito M. Stolfi, Giovanni Tallini & Domenico Cocchia

Authors
  1. Libero Lauriola
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  2. Fabrizio Michetti
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  3. Vito M. Stolfi
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  4. Giovanni Tallini
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  5. Domenico Cocchia
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Lauriola, L., Michetti, F., Stolfi, V.M. et al. Detection by S-100 immunolabelling of interdigitating reticulum cells in human thymomas. Virchows Archiv B Cell Pathol 45, 187 (1984). https://doi.org/10.1007/BF02889864

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  • DOI: https://doi.org/10.1007/BF02889864

Key words

  • Human thymoma
  • Interdigitating reticulum cells
  • S-100 antigen
  • Immunohistochemistry