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The mechanism of epithelial shedding after ischemic damage to the small intestinal mucosa

A light and electron microscopic investigation

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Virchows Archiv B

Summary

The intestinal mucosa of the rat was examined by light and electron microscopy 15, 30, 60 and 120 min after complete ligation of the vessel arcades of the proximal jejunum. The characteristic sign of ischemic damage to the small intestinal mucosa and the reason for epithelial shedding is the appearance of membrane enclosed cytoplasmic blebs which arise at the cell base of the enterocytes and detach the epithelium from the basement membrane. This process begins at the tip of the villi before the enterocytes display signs of irreversible damage and progress to the base of the villi with continuation of the ischemia.

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Authors and Affiliations

  1. Institute for Pathology of the Johannes Gutenberg University of Mainz, Langenbeckstr. 1, D-6500, Mainz, Germany

    R. Wagner, H. Gabbert & P. Höhn

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  1. R. Wagner
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  2. H. Gabbert
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  3. P. Höhn
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With support by the Deutsche Forschungsgemeinschaft.

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Wagner, R., Gabbert, H. & Höhn, P. The mechanism of epithelial shedding after ischemic damage to the small intestinal mucosa. Virchows Arch. B Cell Path. 30, 25–31 (1979). https://doi.org/10.1007/BF02889087

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  • DOI: https://doi.org/10.1007/BF02889087

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