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Acute phase reactants, challenge in the near future of animal production and veterinary medicine

  • Biotechnology and Biomedicine
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Abstract

The future of acute phase proteins (APPs) in science is discussed in this paper. Many functions and associated pathological processes of APPs are unknown. Extrahepatic formation in local tissues needs attention. Local serum amyloid A (SAA) formation may be involved in deposition of AA-amyloid induced by conformational change of SAA resulting in amyloid formation, having tremendous food safety implications. Amyloidogenesis is enhanced in mouse fed beta pleated sheet-rich proteins. The local amyloid in joints of chicken and mammarycorpora amylacea is discussed. Differences in glycosylation of glycoproteins among the APPs, as has been shown for α1-acid glycoprotein, have to be considered. More knowledge on the reactivity patterns may lead to implication of APPs in the diagnostics and staging of a disease. Calculation of an index from values of several acute phase variables increases the power of APPs in monitoring unhealthy individuals in animal populations. Vaccinations, just as infections in eliciting acute phase response seem to limit the profitability of vaccines because acute phase reactions are contraproductive in view of muscle anabolism. Interest is focused on amino acid patterns and vitamins in view of dietary nutrition effect on sick and convalescing animals.

When inexpensive methodology such as liquid phase methods (nephelometry, turbidimetry) or protein array technology for rapid APPs measurement is available, APPs have a future in routine diagnostics. Specific groups of patients may be screened or populations monitored by using APPs.

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Authors and Affiliations

  1. Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

    Gruys E., Toussaint M. J. M., Upragarin N., Ederen A. M. Van, Adewuyi A. A., Candiani D., Nguyen T. K. A. & Sabeckiene (Balciute) J.

  2. Department of Farm Resources and Production Medicine, Faculty of Veterinary Medicine, Kasetsart University, Nakhon Pathom, Thailand

    Upragarin N.

  3. Department of Veterinary Morphophysiology, University of Torino, Italy

    Candiani D.

  4. Department of Embryo Transfer and Reproduction, the National Institute of Animal Husbandry, Hanoi, Vietnam

    Nguyen T. K. A.

  5. Department of Infectious Diseases, Lithuanian Veterinary Academy, Kaunas, Lithuania

    Sabeckiene (Balciute) J.

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Gruys, E., Toussaint, M.J.M., Upragarin, N. et al. Acute phase reactants, challenge in the near future of animal production and veterinary medicine. J. Zhejiang Univ. Sci. B 6, 941–947 (2005). https://doi.org/10.1007/BF02888485

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