Summary
Current methods of conducting clinical trials require the patient to agree to have his treatment assigned randomly, where his individual characteristics are taken into account only to balance the treatment groups. A Bayesian alternative involves eliciting the prior opinions of the group of clinicians who designed the study. Each patient is then guaranteed that the treatment he will receive is the best for him either in the opinion of at least one individual clinician or as a consensus of several, given the patient’s characteristics and all the information available from the trial when the assignment is made.
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References
Bernardo, J.M. (1979). Expected information as expected utility.Ann. Math. Stat.7, 686–690.
Byar, D.P., Simon, R.M., Friedewald, W.T., Schlesselman, J.J., Demets, D.L., Ellenberg, J.N., Gail, M.H. andWare, J.H. (1976). Randomized clinical trials: Perspectives on some recent ideas.N. Engl. J. Med.295, 74.
Dawid, A.P., Dickey, J. andKadane, J.B. (1979). Matrixt and Multivariatet Assessment.Tech. Report, Carnegie-Mellon University
Gilbert, J.P., McPeek, B. andMosteller, F. (1977). Statistics and Ethics in Surgery and Anesthesia.Science198, 684–689.
Good, I.J. (1956). Some terminology and notation in information theory.Proc. IEEE Part C103, 200–204.
— (1978). Ethical Treatments.J. Statist. Comput. Simul 7, 292–295.
Kadane, J.B., Dickey, J., Winkler, R., Smith, W. andPeters, S. (1978). Interactive Elicitation for the Normal Linear Model.Tech. Report, Carnegie-Mellon University.
Lindley, D.V. (1956). On a measure of the information provided by an experiment.Ann. Math. Stat.27, 986–1005.
— (1971).Bayesian Statistics; A Review. Philadelphia: SIAM.
— (1975). The effect of ethical design considerations on statistical analysis.Applied Statist. 24, 218–228.
Peto, R., Pike, M., Armitage, P., Breslow, N.E., Cox, D.R., Howard, S.V., Mantel N., Macpherson, K., Peto, J. andSmith, P.G. (1977). Design and analysis of randomized clinical trials requiring prolonged observation of each patient.B. J. Cancer34, 585;35, 1.
Raiffa, H. andSchlaifer, R. (1961).Applied Statistical Decision Theory. Boston: Harvard Business School.
Savage, L.J. (1954).The Foundations of Statistics. New York: Wiley.
Tukey, J.W. (1977). Some Thoughts on Clinical Trials especially Problems of Multiplicity.Science198, 679–684.
References in the Discussion
COLODNY, R.G. (ed.) (1977).Logic, Laws and Life: Some philosophical considerations. Pittsburg: University Press.
GOOD, I.J. (1969). What is the use of a distribution?. InMultivariate Analysis-II (P.R. Krishnaiah, ed.) 183–203. New York: Academic Press.
GOOD, I.J. (1978). Ethical treatments. InJ. Statist. Comput. and Simulation,7, 292–295.
— (1979). On the combination of judgements concerning quantiles of a distribution with potential application to the estimation of mineral resources.J. Statist. Comput. Simulation 9, 77–79.
— (1979). Review of Colodny (1977).J. Amer. Statist. Assoc. 74, 501–502.
LINDLEY, D.V. (1975). The effect of ethical design considerations on statistical analysis.Applied Statistics 24, 218–228.
RUBIN, D.B. (1978). Bayesian Inference for causal effects: the role of randomization.Ann. Statist. 6, 34–58.
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Kadane, J.B., Sedransk, N. Toward a more ethical clinical trial. Trabajos de Estadistica Y de Investigacion Operativa 31, 329–346 (1980). https://doi.org/10.1007/BF02888358
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DOI: https://doi.org/10.1007/BF02888358