Summary
We used radioimmunoassay to detect platelet-associated IgG and also observed with the electron microscope the interaction between normal mononuclear cells and platelets from ITP children as well as the effect of SPA treatment on the interaction. It was confirmed that ITP was related to the increase of platelet-associated IgG and that platelet-associated IgG did exist on ITP platelets. It was also made clear preliminarily that platelet-associated IgG was bound to ITP platelets mainly through its Fa b terminus with its Fc fragment exposed freely.
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Jun, L., Ling-yi, W. Electron microscopic observation of interaction between normal mononuclear cells and platelets from ITP children. Journal of Tongji Medical University 7, 180–184 (1987). https://doi.org/10.1007/BF02888215
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DOI: https://doi.org/10.1007/BF02888215