Summary
Myocardial perfusion contrast two-dimentional echocardiography (2-DE) is a new method for determining the extent of experimental myocardial ischemia and infarction. 172 aortic root injections of a fresh mixture of 1 ml of 0.75 % hydrogen peroxide (H2O2) and blood, and 75 pulmonary wedge injections of 1 ml of 3 % H2O2 were given to 24 open-chest dogs before and after ligation of the left anterior descending coronary artery (LAD) and four short-axis and long-axis views of the left ventricle were examined. 164 (95%) aortic root injections and 30 (40 %P< 0.05) pulmonary wedge injections showed homogeneous echocardiographic contrast intensification of normal myocardium before ligation of LAD and distinctly delineated echocardiographic contrast defect after ligation of LAD. When compared with aortic root injection, H2O2 pulmonary wedge injection has the adventage of less invasiveness and remains to be further studied.
Similar content being viewed by others
References
DeMaria AN, et al. Echocardiographic visualization of myocardial perfusion by left heart and intracoronary injections of echocontrast agents. Circulation 1980; 62 (Suppl II): II-143.
1985;1:27–31.
Wang XF, et al. Left-sided heart contrast echocardiography by wedge injection of hydrogen peroxide. Chin Med J 1985; 98: 121–6.
Lie JT, et al. Macroscopic enzyme mapping of large homogeneous experimental myocardial infarcts of predictable size and location in dogs. J Thorac Cardiovasc Surg 1975; 69: 599–603.
1981:5; 55–8.
Author information
Authors and Affiliations
Additional information
This project was supported by the Science Fund of the Chinese Academy of Sciences
Rights and permissions
About this article
Cite this article
You-bin, D., Xin-fang, W. & Jia-en, W. Hydrogen peroxide myocardial perfusion contrast echocardiography: I. Experimental study. Journal of Tongji Medical University 7, 143–147 (1987). https://doi.org/10.1007/BF02888207
Issue Date:
DOI: https://doi.org/10.1007/BF02888207