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Ligustrazini inhibits endotoxin induced PAI-1 expression in human umbilical vein endothelial cells

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Summary

Plasminogen activator inhibitor 1 (PAI-1) is one of important coagulant factors. Endotoxin lipopolysaccharide (LPS) induces thrombosis by stimulating PAI-1 secretion of vascular cells (EC). Using sandwich enzyme-linked immunosorbent assay (ELISA) and Northern blot, was investigated the effects of Chinese medicine ligustrazini on PAI-1 expression in EC and LPS-stimulated EC. The results showed that ligustrazini inhibited both basal and LPS-induced PAI-1 mRNA expression in EC. The effect of ligustrazini on LPS-induced PAI-1 secretion worked in a dose-dependent manner. This study provided theoretic and experimental evidence for use of ligustrazini against septic shock and cardiovascular diseases.

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Authors and Affiliations

  1. Department of Pathology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan

    Ruan Qiurong (Associate Professor) & Deng Zhongduan

  2. Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan

    Song Jianxin

Authors
  1. Ruan Qiurong
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  2. Deng Zhongduan
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  3. Song Jianxin
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Additional information

This project was supported by the grant from National Natural Sciences Foundation of China (No. 39730220).

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Qiurong, R., Zhongduan, D. & Jianxin, S. Ligustrazini inhibits endotoxin induced PAI-1 expression in human umbilical vein endothelial cells. Current Medical Science 21, 6–7 (2001). https://doi.org/10.1007/BF02888023

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  • DOI: https://doi.org/10.1007/BF02888023

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