Comparison of effects of magnesium valproate and sodium valproate on the action potential of isolated papillary muscle from guinea pigs and dogs

Summary

A comparison of the effects of magnesium valproate (MV) and sodium valproate (SV) on the action potential of isolated papillary muscle from guinea pigs and dogs was made in this study. The results in both animals were as follows: MV and SV induced a slight reduction of slope plateau of action potential and prolongation of action potential duration (APD).What is more, APD₅₀ and APD₉₀ were prolonged significantly, thus the ratio of APD₉₀/APD₂₅ was increased. The effective refractory period (ERP) was prolonged significantly. MV or SV showed no effects on action potential amplitude, overshoot, resting potential and phase o upstroke velocity. The above results suggested that MV and SV might play an. antiarrhythmic role and that their effects were analogic. The mechanism of MV and SV inducing significant prolongation of APD₅₀, APD₉₀, and ERP, might be closely related to the slow-down of the velocity of K⁺ efflux during plateau and repolarization of phase 3 by radical of valproate and the slow-down of velocity of K⁺ efflux of repolarizalion of phase 3 in particular. These results showed that there was no difference in SV and MV action on guinea pigs and dogs.