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The influence of intracellular cAMP on T cell proliferation

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Summary

The role of AC-cAMP-PKA signal system in T cell activation was investigated by lymphocyte proliferation stimulated by anti-CD3 McAb. The results indicated that AC, cAMP and PKA play important roles in determinirg the responses of lymphocytes to the stimulation. Activation of AC and increase of intracellular cAMP could obviously decrease lymphocyte proliferation, and lymphocyte DNA synthesis was increased to some extent by the pretreatment of PKI.

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Authors and Affiliations

  1. Department of Immunology, Tongji Medical University, 430030, Wuhan

    Li Ming, Yang Jing, Hu Yi-nan, Ye Xian-tao & Ye Wei-xin

  2. Laboratory of Nuclear Medicine, Research Center of Experimental Medicine, Tongji Medical University, 430030, Wuhan

    Hu Yi-nan, Ye Xian-tao & Ye Wei-xin

Authors
  1. Li Ming
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  2. Yang Jing
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  3. Hu Yi-nan
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  4. Ye Xian-tao
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  5. Ye Wei-xin
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Additional information

This work was supported by the China National Natural Science Foundation.

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Ming, L., Jing, Y., Yi-nan, H. et al. The influence of intracellular cAMP on T cell proliferation. Journal of Tongji Medical University 15, 87–89 (1995). https://doi.org/10.1007/BF02887908

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  • DOI: https://doi.org/10.1007/BF02887908

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