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Analysis of plasma fibrinolysis in the patients with acute cerebral infarction

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Summary

In the present study, the plasma fibrinolytic activity in 30 cases of corticaloartery territory cerebral infarction (CACI) and 32 cases of perforating artery territory cerebral infarction (PACI) within 3 days after ictus, and 30 sex- and age-matched controls without cardio-cerebrovascular diseases were evaluated by a comprehensive panel of assay, including the plasma tPA activity, PAI activity, endothelial capacity of tPA release and PAI/tPA ratio. The results showed that the plasma fibrinolysis and the endothelial potential to release tPA responding to stimulation in bcoch subtypes of the patients were significantly lower than those in the controls, which provide the theoretical basis for carrying out the thrombolytic therapy in the ischemic stroke. And the study also suggested that increased plasma PAI activity could increase the risk of AS chrombotic events with increased serum triglyceride level.

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Author notes

  1. Shang Ying-dong

    Present address: Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, 510080, Guangzhou

Authors and Affiliations

  1. Deparlment of Neurology, Tongji Hospital, Tongji Medical University, 430030, Wuhan

    Shang Ying-dong, Liu Xi-min, Cai Zhuan & Yang Ming-shan

Authors
  1. Shang Ying-dong
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  2. Liu Xi-min
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  3. Cai Zhuan
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  4. Yang Ming-shan
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Ying-dong, S., Xi-min, L., Zhuan, C. et al. Analysis of plasma fibrinolysis in the patients with acute cerebral infarction. Journal of Tongji Medical University 15, 68–72 (1995). https://doi.org/10.1007/BF02887904

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  • DOI: https://doi.org/10.1007/BF02887904

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