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A study on hepatitis D virus infection in liver tissues of patients with hepatitis B in China

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Summary

2346 liver samples from 17 areas in China were investigated for intrahepatic hepatitis D antigen (HDAg) by direct enzyme-labelled technique. HDAg was detected in 167 out of 1764 samples of HBsAg positive individuals with the detection rate of 9.47%. Hepatitis D virus (HDV) infection existed in all the examined areas without any significant difference regarding HDAg detection rate. A relationship of intrahepatic HDAg to the pathologic type of the liver disease was observed. The HDAg detection rate in chronic liver diseases and severe hepatitis was higher than in other liver diseases. It suggested that HDV infection was associated with the progression and chronicity of the liver disease. Studies on the relationship between HDV infection and HBV replication showed that HBV replication might be suppressed by HDV infection. Both HDV and HBV, however, could replicate in the same hepatocyte simultaneously.

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Authors and Affiliations

  1. Clinical Immunology Research Unit, Department of Infectious Diseases, Tongji Hospital, Tongji Medical University, Wuhan

    Hao Lian-jie, Li Lin, Zhang Yong-yuan & Song Pei-hui

Authors
  1. Hao Lian-jie
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  2. Li Lin
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  3. Zhang Yong-yuan
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  4. Song Pei-hui
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Lian-jie, H., Lin, L., Yong-yuan, Z. et al. A study on hepatitis D virus infection in liver tissues of patients with hepatitis B in China. Journal of Tongji Medical University 10, 65–68 (1990). https://doi.org/10.1007/BF02887862

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