Summary
In mongrel rabbits intracerebroventricular microinjected angiotensin III (A III, 4 nmol) and angiotensin II (A II 4 nmol) equally evoked increase of mean arterial pressure and decrease of heart rate respectively. However, intracerebroventricular preinjection of saralasin, prazosin or arginine-vasopressin antiserum or intravenous preinjection of phentolamine could markedly attenuate the above cardiovascular effects of A III and A II respectively. The results indicated that the response intensity and mechanism of the central presser effect of A III were similar to those of A II.
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Cheng-gao, Y., Zhen-ying, W., Shi-yi, Z. et al. Effects of intracerebroventricular microinjection of angiotensin III on the cardiovascular activities in rabbits. Journal of Tongji Medical University 8, 98–100 (1988). https://doi.org/10.1007/BF02887803
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DOI: https://doi.org/10.1007/BF02887803