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Response of melanoma cells to α- MSH and cAMP stimulation

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Summary

A melanotic clone of the Claudmann S-91 melanoma was treated with 2 × 10™7M α-MSH and 10™3M cAMP. By fluorometric assay and electron microscopy it was found that these agents enhanced melanin content and melanosomes in cytoplasm, inhibited cell growth and incuced morphologic alterations, such as appearance of hypertrophy and dendrite-like formation.

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Authors and Affiliations

  1. Department of Anatomy, Tongji Medical University, Wuhan

    Liu Yun-hua

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  1. Liu Yun-hua
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Yun-hua, L. Response of melanoma cells to α- MSH and cAMP stimulation. Journal of Tongji Medical University 8, 89–93 (1988). https://doi.org/10.1007/BF02887801

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  • DOI: https://doi.org/10.1007/BF02887801

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