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Mechanism and significance of abnormal blood level of β2-microglobulin in patients with Graves’ disease

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Summary

The blood-level of β2-microglobulin (β2-mG) in patients with Graves disease is generally elevated, varying with the condition of the patients. After treatment with Tapazole, the blood level of β2-mG is gradually lowered to normal range with improvement of the disease. In this study the mechanism and significance of such variations of β2-mG in Graves disease patients were investigated by observing suppressor T-lymphocyte function (expressed as suppression index, SI). At the same time the blood levels of β2-mG of the same subjects were determined. It was found that the quantitative variation of the blood β2-mG was related to the condition of patients as well as to the status of immunologic system. The high level of blood β2-mG was probably due to the dysfunction of suppressor T-lymphocytes. The measurement of blood β2-mG was much easier than that of SI, and possibly, the former could be used instead of the latter to show the function of cell-mediated immunity in patients with Graves disease.

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Authors and Affiliations

  1. Xiehe Hospital, Tongji Medical University, Wuhan

    Han Xiao-liang & Yie Wei-xin

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  1. Han Xiao-liang
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  2. Yie Wei-xin
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Xiao-liang, H., Wei-xin, Y. Mechanism and significance of abnormal blood level of β2-microglobulin in patients with Graves’ disease. Journal of Tongji Medical University 8, 35–40 (1988). https://doi.org/10.1007/BF02887775

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  • DOI: https://doi.org/10.1007/BF02887775

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