Summary
To investigate the relationship between proliferative capacity of salivary gland cells in contiguous acini of parotid tumors and recurrent neoplasma, DNA contents of 30 fresh specimens of parotid were studied by using cytometry in tumors, normal and shallow or deep lobe acini of the masses. The results showed that the DI was 1.369, S % 16.95, PI 26.18 in malignant tumors; DI was 1.171, S % 12.41, PI 15.54 in recurrent pleomorphic adenoma; DI was 1.141, S % 12. 74, PI 13.07 in pleomorphic adenoma, DI was 0.999, S % 5.10, PI 8.00 in normal acini. Analysis of variance showed there was a significant difference (P < 0.01). The average DNA contents of shallow on deep lobe of contiguous tumors was 1.08 in DI, 10.65 in S %, 13.49 in PI in malignant tumor, 1.06 in DI, 8.96 in S % and 9.85 in PI in pleomorphic adenoma, which were all higher than in normal acini (P > 0.05). It was concluded that the levels of DI and S % of parotid tumor and its contiguous acini are related to degree of malignancy or recurrent condition of the tumors, suggesting contiguous acini of parotid tumors had the strong capacity of proliferation, which might play an important role in recurrent or malignant change of the parotid tumors.
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References
1996, 16:121
1996, 2: 59
1996, 31:67
1997, 32:67
1998, 33:259
Dardick I, Byard R W, Carnegie J A. A review of the proliferative capacity of major salivary glands and the relationship to current concepts of neoplasia in salivary glands. Oral Surg, 1990, 69: 53
Kahn M A, Docdter M E, Hermann-Petrin J M. Flow cytometor analysis of oral premalignant lesion: a plot and review. J Oral Pathol Med, 1992, 21: 1
Frarzen G, Nordgard S, Boyserm Met al. DNA content in adenoid cystic carcinoma. Head Neck Surg, 1995, 47: 49
Brandwein M, Huros A G, Dardick Iet al. Noninvasive and minimally invasive carcinoma ex mixed tumor: a clinicopathologic and ploidy study of 12 patients with salivary tumors of low malignant potential. Oral Surg, 1996, 81: 655
Daniele E, Tralongo v, Morello Vet al. Pleomorphic adenoma and adenoid cystic carcinoma of salivary gland immunohistochemical assessment of proliferative activity in comparison with flow cytometric study. Cell Prolif, 1996, 29: 153
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Shengrong, Z., Xiuli, W., Lenan, S. et al. Flow cytometric analysis of DNA content in parotid tumor and its contiguous acini. Current Medical Science 20, 86–88 (2000). https://doi.org/10.1007/BF02887687
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DOI: https://doi.org/10.1007/BF02887687