Summary
The effects of pro-hepatocyte growth factor (pHGF) on the changes of renal cellular proliferative cycle of partial hepatectomized rats were observed by flow cytometry (FCM). S phase fraction (SPF) of control rats (group A) accounted for 7.58 % and increased gradually within 6 h, following a peak at 12th or 36th h after operation, but in pHGF-treated rats (group B) the peak appeared at 24th h after operation. Proliferation index (PI) of group A was 13.2 % before partial hepatectomy, increased within 6 h and reached a peak at 12th or 36th h after operation, and in group B the peak appeared at 48th h after operation. There were significant differences in SPF and PI between two groups (P < 0.01). These findings suggest that pHGF may non-specifically promote the DNA synthesis of renal cells.
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Jiazhi, L., Wangxian, T., Junping, W. et al. Effects of pHGF on renal cellular DNA synthesis after partial hepatectomy in rats. Current Medical Science 20, 55–56 (2000). https://doi.org/10.1007/BF02887677
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DOI: https://doi.org/10.1007/BF02887677