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Effects of aprotinin on serum interleukin-2 and soluble interleukin-2 receptor during cardiopulmonary bypass

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Summary

Interleukin-2 and its receptor are of importance in regulating immunity responses. The changes of interleukin-2 (IL-2) and soluble interleukin-2 receptor (IL-2R) during heart valve (s) replacement operation and effects of aprotinin on them were observed. Twenty patients undergoing heart valve(s) replacement were randomly divided into two groups: control group (n=10) and aprotinin group (n=10). In aprotinin group, 1 000 000 KIU aprotinin was given by vein injection and then 2 000 000 KIU was given as a bolus in prime. Blood samples were collected before CPB, right after CPB and on the 1st, 3rd and 7th postoperative day (POD) for serum IL-2 and sIL-2R determination. Results showed that after CPB, IL-2 was reduced and sIL-2R increased. Meanwhile, serum IL-2R was lower in aprotinin group than that of control. It is concluded that the immunity depression after CPB is associated with low level of IL-2 and high level of sIL-2R and aprotinin can ameliorate the situation.

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Authors and Affiliations

  1. Department of Heart Surgery, Institute of Cardiovascular Diseases, Tongji Medical University, 430022, Wuhan

    Luo Jun M. D., Ph.D., Wang Dongfang, Lan Hongjun & Sun Zongquan

Authors
  1. Luo Jun M. D., Ph.D.
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  2. Wang Dongfang
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  3. Lan Hongjun
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  4. Sun Zongquan
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Additional information

This project was supported by a grant from the National Natural Science Foundation of China (No. 39270658).

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Jun, L., Dongfang, W., Hongjun, L. et al. Effects of aprotinin on serum interleukin-2 and soluble interleukin-2 receptor during cardiopulmonary bypass. Current Medical Science 20, 143–144 (2000). https://doi.org/10.1007/BF02887056

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  • DOI: https://doi.org/10.1007/BF02887056

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