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Platelet fibrinogen in the patients with idiopathic bleeding platelet disorder

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Summary

The changes of platelet fibrinogen in patients with obscure cutaneous mucosal bleeding and their relation with disease were evaluated. By using flow cytometry and Western blot, the platelet binding site of fibrinogen and the expression of platelet fibrinogen in 8 cases of obscure bleeding were detected. The results showed that platelet surface binding sites of fibrinogen were 65.38±3.62 in the resting state and 65.25±5.78 after activated by adenosine diphosphate, showing no significant difference as compared with control group (P>0.05). The expression of platelet fibrinogen was obviously decreased in 4 patients and increased in one case as compared with control group. It was concluded that the binding sites of fibrinogen on the platelet surface were normal in the patients with idiopathic bleeding platelet disorder. The abnormal of platelet fibrinogen might be one of hemorrhagic reasons in partial patients.

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Author notes

  1. Yang Linhua M. D.

    Present address: Department of Hematology, The Second Hospital of Shanxi Medical University, 030001, Taiyuan

Authors and Affiliations

  1. Institute of Hematology, Tongji Medical University, 430022, Wuhan

    Yang Linhua M. D., Shen Di, Wang Ailian, Wei Wenning, Liu Zhongping, Yang Rui, Yang Yan & Zhang Yujin

Authors
  1. Yang Linhua M. D.
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  2. Shen Di
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  3. Wang Ailian
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  4. Wei Wenning
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  5. Liu Zhongping
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  6. Yang Rui
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  7. Yang Yan
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  8. Zhang Yujin
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Additional information

This project was supported by a grant from the National Natural Science Foundation of China (No. 393703322).

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Linhua, Y., Di, S., Ailian, W. et al. Platelet fibrinogen in the patients with idiopathic bleeding platelet disorder. Current Medical Science 20, 134–136 (2000). https://doi.org/10.1007/BF02887052

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  • DOI: https://doi.org/10.1007/BF02887052

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