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Toxicity of magnetic albumin microspheres bearing adriamycin

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Summary

Magnetic albumin microspheres bearing adriamycin (ADM-MAM) is a novel chemotherapeutic compound with site-specific drug delivery characteristics. The acute and subacute toxic tests of the compound, local irritating test and anaphylactic test were performed on mice and guinea pigs. The results showed there was no macroscopically and microscopically direct cytotoxic injuries ofthe compound to the animal organs or to the cells. The LD50 value of the compound was higher than that of the single used adriamycin, indicating that the compound was less toxic than the single adriamycin and quite safe in its therapeutic dosage. Furthermore, there was also no side effects or toxic reactions to be observed on clinical patients with advanced carcinoma or gastric cancer.

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Authors and Affiliations

  1. Department of General Surgery, Xiehe Hospital, Tongji Medical University, 430022, Wuhan

    Ma Jianhua (Doctor in Charge), Chen Daoda, Tian Yuan & Tao Kaixiong

Authors
  1. Ma Jianhua
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  2. Chen Daoda
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  3. Tian Yuan
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  4. Tao Kaixiong
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Additional information

This project was supported by a grant from the National Key Tasks’ foundation (No. 969060116).

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Jianhua, M., Daoda, C., Yuan, T. et al. Toxicity of magnetic albumin microspheres bearing adriamycin. Current Medical Science 20, 261–262 (2000). https://doi.org/10.1007/BF02887008

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  • DOI: https://doi.org/10.1007/BF02887008

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