Summary
One hundred and eighty-two SD rats were randomly divided into the normal control group, fast operating group and food-intake operating group. The experimental model of acute pancreatitis (AP) in rats was established by injecting 5 % sodium taurocholate into the pancreatic duct of rat according to Aho’s method. The sandostatin was used for positive contrast. The concentrations of serum amylase, calcium, C reaction protein (CRP) and interleukin-6 (IL-6) were assayed respectively at different time points. The pathological sections were observed. Each operating group contained 10 rats. The mortality of the operating groups was observed during the 24 h. The serum amylase level in the AP rats was reduced after receiving vagotomy (VG,P < 0.05). Although the serum calcium level in most groups was decreased, the reduction in the group with VG plus sandostatin was not obvious (P > 0.05). The increase of CRP and IL-6 was not obvious after VG (P > 0.05). The change of mortality was not significant (P > 0.05). The pathological sections showed that the AP pathological change was mild after VG. The disease condition of food-intake operating group was more serious than that of fast operating group. It was suggested that VG had some influence on the prognosis of AP in rats.
Similar content being viewed by others
References
1991, 11(3):l72
1999, 26(2):88
Aho H J, Horn S S, Topalian S Let al. Experimental pancreatitis in the rat: Sodium taurocholate-induced acute hemorrhagic pancreatitis. Scand J Gastroenterol, 1980, 15:411
Pavlov I P. The work of the digestive glands. London. Translated by WT Thompson. Griffin, 1902.
Li J S, Chen D D, Tian Yet al. DNA content in pancreatic exocrinal cell after vagotomy and electron microscopy in rats. J Tongji Med Univ, 1999, 19(3):223
Sinev I V. Endoscopic pharmacologic denervation of the stomach in the treatment of acute pancreatitis. Khirurgiia —Mosk, 1992, Jan(1):58
Gerzilov P. Transendoscopic drug denervation of the stomach in emergency surgical disease of the gastrointestinal tract (a preliminary report). Khirurgiia-Sofiia, 1996, 49(6):17
1994, 21(5):264
1996, 23(2):69
Anagostides A, Chadwick V S, Seiden A Cet al. Sham feeding and pancreatic secretion: evidence for direct vagal stimulation of enzyme output. Gastroenterology, 1984, 87:109
Li Y. Somatostatin inhibits pancreatic enzyme secretion at a central vagal site. Am J Physiol, 1993, 265(2):G251
Kiba T, Tanaka K, Numata Ket al. Ventromedial hypothalamic lesion induced vagal hyperactivity stimulates rat pancreatic cell proliferation. Gastroenterology, 1996, 110:885
Sanfey H. Increased capillary permeability: An early lesion in acute pancreatitis. Surgery, 1984, 96(3):485
Schroder T. Microcirculatory effects of Somatostatin in acute pancreatitis. Eur Surg Res, 1988, 20(1):82
1995, 75(4): 244
Joseph P H. Laser laparoscopic vagotomy and pylovomyotomy. Gastrointest Endosc, 1991, 37:338
1995, 22(2):118
Chisbolm E M. Thoracoscopic vagotomy: a new use of the laparoscope. Br J Surg, 1992, 79:254
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jinsong, L., Jiongxin, X., Daoda, C. et al. Effect of vagotomy on acute pancreatitis in rats. Current Medical Science 20, 235–238 (2000). https://doi.org/10.1007/BF02887001
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02887001