Summary
The model of SD rats ligated at the proximate left anterior descend (LAD) of coronary was used. The number and dissociation constant of β receptor were studied by using receptor autoradiography to observe the changes in β receptor and the effects of Radix Ginseng Rubra on cAMP in experimental ischemic my-ocardium. The result showed that the number of binding site in simple ligation group (Bmax = 0. 279) was obviously higher than that in sham operation group (Bmax = 0. 093) and the dissociation constant of simple ligation group (Kd = 12. 431) was higher than that of sham operation group (kd = l. 319). There was a significant difference between the two groups (P<0. 05). It proved that the number of β receptor was increased and the activity was elevated in myocardial cell membranes after ligation of LAD. The myocardial cAMP level in simple ligation group [(1293. 96±519. 36) × 10-3 nmol/g] was much higher than that in sham operation group [(774. 44 ±210. 55) × 10-3nmol/g]; but the level of cAMP in ligation group after receiving Radix Ginseng Rubra treatment (805. 02 ±362. 48 pm/g) was obviously lower than that in simple ligation group (P<0. 01), which was close to the result of sham operation. The results indicated that Radix Ginseng Rubra could decrease the cAMP level in ischemic myocardium.
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This project was supported by grants from National Natural Science Foundation of China (No. 3870563).
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Zhengxiang, L., Jian, Z., Xingbiao, O. et al. The effects of Radix Ginseng Rubra on cAMP of experimental ischemic myocardium in rats. Current Medical Science 19, 90–92 (1999). https://doi.org/10.1007/BF02886882
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DOI: https://doi.org/10.1007/BF02886882