Summary
In 72 obese women body mass index positively correlated with age and both showed multiple correlations with serum lipids and lipoprotein lipids. After adjustment for age (partial correlation procedure), body mass index resulted to be positively correlated with serum triglycerides, VLDL lipids, HDL-triglycerides and negatively correlated with HDL-cholesterol. The decrease in HDL-cholesterol concentration along with the increase in body weight was due to the reduction of cholesterol in DHL2 subfraction, while HDL3-cholesterol did not show any significant correlation with body mass index. The negative correlation between HDL2-cholesterol and body mass index was independent of other lipoprotein variables and in particular of VLDL lipid levels that were, as expected, inversely related to HDL2-cholesterol. HDL2-cholesterol is believed to be a strong protective factor against atherosclerosis, while doubts exist on the meaning of VLDL lipids as risk factors. Thus, the decrease in HDL2-cholesterol concentration, rather than the increase in VLDL lipids, might give a rational basis to the high incidence rate of vascular disease in obese subjects.
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Anderson D. W., Nichols A. V., Pan S. S., Lindgren F. T.: High density lipoprotein distribution. Resolution and determination of three major components in a normal population sample — Atherosclerosis29, 161, 1978.
Avogaro P., Bittolo Bon G., Cazzolato G., Quinci G. B.: Lipoproteins and apolipoproteins A-I and B in obese subjects in basal state and following a hypocaloric diet. In:Noseda G., Lewis B., Paoletti R. (Eds): Diet and drugs in atherosclerosis. Raven Press, New York, 1980; p. 67.
Castelli W. P., Doyle J. T., Gordon T. G., Hames C. G., Hjörtland M. C., Hulley S. B., Kagan A., Zuckel W. J.: HDL-cholesterol and other lipids in coronary heart disease. The Cooperative Lipoprotein Phenotyping Study — Circulation55, 2089, 1977.
Dyer A. R., Stamler J., Berkson D. M., Lindberger M. A.: Relationship of relative weight and body mass index to 14-year mortality in the Chicago Peoples Gas Company Study — J. chron. Dis.28, 109, 1975.
Eder H. A., Gidez L. I.: The clinical significance of the plasma high density lipoproteins — Med. Clin. N. Amer.66, 431, 1982.
Fellin R., Baggio G., Baiocchi M. R., Martini S., Baldo G., Manzato E., Crepaldi G.: HDL2 and HDL3 variations during the postprandial phase in humans. In:Noseda G., Lewis B., Paoletti R. (Eds): Diet and drugs in atherosclerosis. Raven Press, New York, 1980; p. 85.
Garrison R. J., Wilson P. W., Castelli W. P., Feinleib M., Kannell W. B., McNamara M.: Obesity and lipoprotein cholesterol in the Framingham Offspring Study — Metabolism29, 1053, 1980.
Gordon T., Kannell W. B.: Predisposition to atherosclerosis in the head, heart and arms. The Framingham Study — J. Amer. med. Ass.221, 661, 1972.
Hulley S. B., Rosenman R. H., Bawol R. D., Brand R. J.: Epidemiology as a guide to clinical decision: the association between triglyceride and coronary heart disease — New Engl. J. Med.302, 1383, 1980.
Huttunen J. K., EhnholmC., Kekki M., NikkilÄ E. A.: Post-heparin plasma lipoprotein lipase and hepatic lipase in normal subjects and in patients with hypertriglyceridemia: correlations to sex, age and various parameters of triglyceride metabolism — Clin. Sci. molec. Med.50, 249, 1976.
Keys A.: Overweight, obesity, coronary heart disease and mortality — Nutr. Rev.38, 297, 1980.
Keys A., Aravanis C., Blackburn H., Van Buchem F. S. P., Buzina R., Djordjevic B. S., Fidanza F., Karvonen M. J., Menotti A., Puddu V., Taylor H. L.: Coronary heart disease, overweight and obesity as risk factors — Ann. intern. Med.77, 15, 1972.
Lithell H., Boberg J.: The lipoprotein-lipase activity of adipose tissue from different sites in obese women and relationship to cell size — Int. J. Obesity2, 47, 1978.
Mancini M., Di Biase G., Contaldo F., Fischetti A., Grasso L., Mattioli P. L.: Medical complications of severe obesity: importance of treatment by very low-calorie diets. Intermediate and long-term effects — Int. J. Obesity5, 341, 1981.
Miller G. J., Miller N. E.: Plasma high density lipoprotein concentration and development of ischaemic heart disease — Lanceti, 16, 1975.
Miller N. E., Hammet F., Saltissi S., Rao S., Van Zeller H., Coltart J., Lewis B.: Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins — Brit. med. J.282, 1741, 1981.
National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance — Diabetes28, 1039, 1979.
Nestel P. J., White H. M.: Plasma free fatty acid and triglyceride turnover in obesity — Metabolism17, 1122, 1968.
Nikkilä E. A., Taskinen M. R., Harno K.: Plasma triglyceride metabolism in human obesity. In:Mancini M., Lewis B., Contaldo F (Eds): Medical complications of obesity. Academic Press, London, 1979; p. 101.
Olefsky J. M., Farquhar J. W., Reaven G. M.: Reappraisal of the role of insulin in hypertriglyceridemia — Amer. J. Med.57, 551, 1974.
Olefsky J. M., Reaven G. M., Farquhar J. W.: Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects — J. clin. Invest.53, 64, 1974.
Patsch J. R., Gotto A. M. Jr.,Olivecrona T., Eisenberg S.: Formation of high-density lipoprotein2-like particles during lipolysis of very low density lipoproteinsin vitro — Proc. nat. Acad. Sci. (Wash.)75, 4519, 1978.
Persson B.: Lipoprotein lipase activity of human adipose tissue in health and in some diseases with hypertriglyceridemia as a common feature — Acta med. scand.193, 447, 1973.
Pooling Project Group: Relationship of blood pressure, serum cholesterol, smoke habit, relative weight and ECG abnormalities to incidence of major coronary events. Final report of the Pooling Project — J. chron. Dis.31, 201, 1978.
Pykalisto D. J., Smith P. H., Brunzell J. D.: Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal and diet-induced activity — J. clin. Invest.56, 1108, 1975.
Snedecor G. W., Cochran W. G.: Statistical methods. 6th ed. Iowa State University Press, Ames, Iowa, 1967;
Taskinen M. R., Nikkilä E. A.: Lipoprotein lipase activity in adipose tissue and in postheparin plasma in human obesity — Acta med. scand.202, 399, 1977.
Taskinen M. R., Nikkilä E. A., Ehnholm C.: Effect of parenteral hyperalimentation on serum lipoproteins and on lipoprotein lipase activity of adipose tissue and skeletal muscle — Europ. J. clin. Invest.11, 317, 1981.
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Sommariva, D., Tirrito, M., Bellintani, L. et al. Interrelationships between body mass and lipid and lipoprotein triglycerides and cholesterol in obese women. La Ricerca Clin. Lab. 16, 481–488 (1986). https://doi.org/10.1007/BF02886744
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DOI: https://doi.org/10.1007/BF02886744