Summary
Two hundred and forth household contacts of 85 chronic HBsAg carriers were studied to assess the relationship between liver histology and ‘e’ antigen or antibody positivity in the index carrier, and evidence of HBV infection within the family. Liver biopsy results were available in 54 index carriers. The prevalence of HBsAg and anti-HBs in the families of 29 carriers with chronic hepatitis and 25 carriers with either a normal liver or minimal inflammatory changes was not significantly different. Serum from 72 index carriers was available for HBeAg and anti-HBe testing. The prevalence of HBsAg and anti-HBs in the families of 5 HBeAg positive carriers, 59 anti-HBe positive subjects, and 8 carriers negative for both HBeAg and anti-HBe was again not significantly different. Infectivity of a carrier thus does not appear to correlate either with histological evidence of liver damage or with the ‘e’ antigen or antibody positivity of the carrier.
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Alberti A., Diana S., Scullard G. H., Eddleston A. L. W. F., Williams R.: Full and empty Dane particles in chronic hepatitis B virus infection: relation to hepatitis-B-e-antigen and presence of liver damage — Gastroenterology75, 869, 1978.
Blumberg B. S., Melartin L., Guinto R. A., Werner B.: Family studies of a human serum isoantigen system (Australia antigen) — Amer. J. hum. Genet.18, 594, 1966.
de Franchis R.: Unpublished data.
de Franchis R., D’Arminio A., Vecchi M., Ronchi G., Del Ninno E., Parravicini A., Ferroni P., Zanetti A. R.: Chronic asymptomatic HBsAg carriers: liver histology and diagnostic and prognostic value of the serologic markers of the HBV — Gastroenterology79, 521, 1980.
Grady G. F.: Relation of e antigen to infectivity of HBsAg positive inoculations among medical personnel — Lancetii, 492, 1976.
Heathchote J., Gateau P., Sherlock S.: Role of hepatitis-B antigen carriers in non-parenteral transmission of the hepatitis-B virus — Lancetii, 370, 1974.
Helske T.: Carriers of hepatitis B antigen and transfusion hepatitis in Finland — Scand. J. Haemat.22 (Suppl.), 1, 1974.
Hess G., Arnold K., Meyer zum Buschenfelde H.: Comparison of indicators of Dane particles — Klin. Wschr.58, 371, 1980.
Howard C. R., Zanetti A. R., Thal S., Zuckerman A. J.: Viral antigens and antibodies in hepatitis B infection — J. clin. Path.31, 681, 1978.
Inaba N., Ohkawa R., Matsuura A., Kudoh J., Takamizawa H.: Sexual transmission of hepatitis B surface antigen. Infection of husbands by HBsAg carrier-state wives — Brit. J. vener. Dis.55, 366, 1979.
International Forum: How should a carrier of hepatitis B surface antigen be cared for with regard to clinical investigation, general counseling and occupational restrictions? — Vox Sang. (Basel)34, 310, 1978.
Magnius L. O., Lindholm A., Lundin P., Iwarson S.: A new antigen-antibody system. Clinical significance in long-term carriers of hepatitis B surface antigen — J. Amer. med. Ass.231, 356, 1975.
Nordenfelt E., Andren-Sandberg M.: Dane-particle associated DNA polymerase and e antigen: relation to chronic hepatitis among carriers of hepatitis B surface antigen — J. infect. Dis.134, 85, 1976.
Nordenfelt E., Dahlquist E.: HBsAg positive adopted children as a cause of intrafamilial spread of hepatitis B — Scand. J. infect. Dis.10, 161, 1978.
Nordenfelt E., Kjellén L.: Dane particles, DNA polymerase, and e antigen in two different categories of hepatitis B antigen carriers — Intervirology5, 225, 1975.
Okada K., Kamiyama I., Inomata M., Imai M., Myakawa Y., Mayumi M.: e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants — New Engl. J. Med.294, 746, 1976.
Palmer Beasley R., Trepo C., Stevens C. E., Szmuness W.: The e antigen and vertical transmission of hepatitis B surface antigen — Amer. J. Epidem.105, 94, 1977.
Perrillo R., Gelb L., Campbell C., Wellinghof W., Ellis F. R., Overby L., Aach R. D.: Hepatitis B e antigen, DNA polymerase activity and infection of household contacts with hepatitis B virus — Gastroenterology76, 1319, 1979.
Realdi G., Alberti A., Rugge M., Bortolotti F., Rigoli A. M., Tremolada F., Ruol A.: Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection — Gastroenterology79, 195, 1980.
Schweitzer H., Edwards V. M., Brezina M.: e antigen in HBsAg carrier mothers — New Engl. J. Med.293, 940, 1975.
Singleton J. W., Kohler P. F., Merrill D. A.: Infectivity risk of household contact with chronic carriers of hepatitis B antigen — Gastroenterology64, 172, 1973.
Skinhöj P., Cohn J., Bradbourne A. F.: Transmission of hepatitis type B from healthy HBsAg positive mothers — Brit. med. J.i, 10, 1976.
Stevens C. E., Neurath R. A., Palmer Beasley R., Szmuness W.: HBeAg and anti-HBe detection by radioimmunoassay: correlation with vertical transmission of hepatitis B virus in Taiwan — J. med. Virol.3, 237, 1979.
Szmuness W.: Recent advances in the study of the epidemiology of hepatitis B — Amer. J. Path.81, 629, 1975.
Szmuness W., Harley E. J., Prince A. M.: Intrafamilial spread of asymptomatic hepatitis B — Amer. J. med. Sci.270, 292, 1975.
Szmuness W., Prince A. M., Hirsch R. L., Brotman B.: Familial clustering of hepatitis B infection — New Engl. J. Med.289, 1162, 1973.
Zanetti A. R., Magliano E. M., Ferroni P., Pirovano G., Tanzi E., Moro M.: Vertical transmission of HBV from asymptomatic HBsAg carrier mothers to their infants — In: 15th Meeting of the European Association for the Study of the Liver. Belgrade, September 1980. (Abstract no. 51).
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de Franchis, R., D’Arminio, A., Viganò, F. et al. Intrafamilial spread of hepatitis B virus infection. La Ricerca Clin. Lab. 11, 151–158 (1981). https://doi.org/10.1007/BF02886715
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DOI: https://doi.org/10.1007/BF02886715