Summary
Cells taken from draining lymph nodes one day after application of oxazolone and picryl chloride induced contact sensitivity in syngeneic but not in allogeneic recipients. In contrast, the immunizing activity of cells taken four days after sensitization was not genetically restricted. The findings that ‘1-day’ cells incubated with anti-hapten antibodies break down the genetic restriction, and that ‘4-day’ cells lose their ability to induce contact sensitivity after complement treatment, suggest that two different mechanisms are involved in the induction of contact sensitivity.
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Asherson G. L., Mayhew B., Perera M. A. C. C.: The production of contact sensitivity by the injection into the footpad of recipients of the lymph node cells from mice 1 day after painting their skin with contact sensitizing agents: requirement for matching at the major histocompatibility complex between donor and recipient mice — Immunology37, 241, 1979.
Asherson G. L., Zembala M., Mayhew B.: Analysis of the induction phase of contact sensitivity by footpad transfer of regional lymph node cells: macrophages and radioresistant T cells induce immunity — Immunology32, 81, 1977.
Asherson G. L., Zembala M., Thomas W. R., Perera M. A. C. C.: Suppressor cells and the handling of antigen — Immunol. Rev.50, 3, 1980.
Colizzi V., Bozzi L.: A mechanism for the depression of contact sensitivity with B-cell mitogens — Ann. Inst. Pasteur130C, 659, 1979.
Garzelli C., Colizzi V., Campa M., Bozzi L., Falcone G.: Depression of contact sensitivity byPseudomonas aeruginosa-induced suppressor cells which affect the induction phase of immune response — Infect. Immun.26, 4, 1979.
Geiger B., Rosenthal K., Klein J., Zinkernagel R. M., Singer S. J.: Selective and unidirectional membrane redistribution of an H-2 antigen with an antibody-clustered viral antigen: relationship to mechanisms of cytotoxic T-cell interactions — Proc. nat. Acad. Sci. (Wash.)76, 4603, 1979.
Little G. R., Eisen H. N.: Preparation and characterization of antibodies specific for the 2,4,6-trinitrophenyl group — Biochemistry5, 3385, 1966.
Miller J. F. A. P., Vadas M. A., Whitelaw A., Gamble J.: Role of major histocompatibility complex gene products in delayed-type hypersensitivity — Proc. nat. Acad. Sci. (Wash.)73, 2486, 1976.
Ptak W., Rozycka D., Askenase P. W., Gershon R. K.: Role of antigen-presenting cells in the development and persistence of contact hypersensitivity — J. exp. Med.151, 362, 1980.
Shevach E. M., Rosenthal A. S.: Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response — J. exp. Med.138, 1213, 1973.
Unanue E. R., Feldman J. D.: Role of macrophages in delayed hypersensitivity. I. Induction with macrophage-bound antigen — Cell. Immunol.2, 269, 1971.
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This work was partly carried out at the Department of Immunological Medicine, Clinical Research Centre, Harrow, Middlesex, Great Britain, and was supported by grant no. 133.3093 ofConsiglio Nazionale delle Ricerche (CNR), Roma, Italy.
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Colizzi, V. Genetic restriction in the induction of contact sensitivity by footpad cell transfer. La Ricerca Clin. Lab. 11, 123–128 (1981). https://doi.org/10.1007/BF02886711
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DOI: https://doi.org/10.1007/BF02886711