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Alterations in rat erythrocyte membrane parameters during Calcium oxalate lithiasis and effect of DL α-lipoic acid

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Abstract

The effect of DL α-lipoic acid, a potent antioxidant was studied in relation to certain erythrocyte membrane parameters in calcium oxalate stone forming rats. Induction of calcium oxalate lithiasis was done by feeding a diet containing 3% w/w sodium glycollate. Erythrocyte membrane (Na+, K+)-ATPase showed a significant decrease in stone formers whereas (Ca2+)-ATPase showed a significant increase. Lipoic acid administration brought about an elevation in the activity of (Ca2+)-ATPase. Changes in membrane (Mg2+)-ATPase was minimal. Membrane cholesterol and phospholipids were found raised significantly in lithogenic rats. The changes may be attributed to enhanced lipid peroxidative mechanisms and altered serum lipid profile observed in this group. Treatment with lipoic acid reduced membrane cholesterol levels. Phospholipids were also decreased moderately. The above observations suggest that lipoic acid administration to calculogenic rats reduces the erythrocyte strucutral changes observed in this condition.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Dr. A.L.M. Post Gradnate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, 600 113, Madras, India

    S. Jayanthi & P. Varalakshmi

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  1. S. Jayanthi
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  2. P. Varalakshmi
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Jayanthi, S., Varalakshmi, P. Alterations in rat erythrocyte membrane parameters during Calcium oxalate lithiasis and effect of DL α-lipoic acid. Indian J Clin Biochem 7, 115–120 (1992). https://doi.org/10.1007/BF02886663

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