Summary
Cu, Zn, Mn, Se were determined in erythrocytes in 43 patients with gestational trophoblastic disease(GTD), and T cell subsets were also monitored in peripheral blood in 37 cases.The results revealed that the contents of Cu and Se in erythrocytes in patients with GTD were significantly higher than those in normal females, the contents of Zn in patients with hydatidiform mole(HM) and Mn in patients with GTD were significantly lower than those in normal females, and so were the absolutes of lymphocytes, T cell and T subsets in peripheral blood in patients with GTD, the T4 +/T8 + ratio in patients with HM and high risk gestational trophoblastic tumor(GTT) was obviously lower than that in normal controls. The above findings led us to hold thac the alteration of crace elements(TE) in patients with GTD affects their immunologic function and is closely related to the occurrence and development of GTD.
Similar content being viewed by others
References
Lao TTh, et al. Changes in erythrocyte and plasma zinc concentrations in pregnancy. Gynecol Obstet Invest, 1988, 25(3):213.
Pieter van’t Veer, et al. Selenium in diet, blood and toenails in relation to breast cancer: A case-control study. Am J Epidermiol, 1990,13(6):987
Hantano S, et al. Copper levels in plasma and erythrocytes in healthy Japanese children and adult. Am J Clin Nutr, 1982,35(1):120
Flynn A. Control of in vitro lymphocyte proliferation by copper, magnesium and zinc deficiency. J Nutr, 1984,114:2034.
Chandra RK, et al. Excessive intake of Zinc impairs immune-response. JAMA, 1984,252:328
Agarwal K, et al. Clastogenic effects of copper sulfate on the bone marrow chromosomes of mice in vivo. Mutat Res, 1990,243(1):1
Khalil AM. The induction of chromosomes, aberations in human purified peripheral blood lymphocytes following in viro exposure to selenium. Mutat Res, 1989,224(4):503
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chang-yu, W., Xiu-mei, Q. Studies on some trace elements and cell-mediated immunity in patients with gestational trophoblastic disease. Journal of Tongji Medical University 13, 51–55 (1993). https://doi.org/10.1007/BF02886595
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02886595