Summary
The incidence of the co-infection of hepatitis G virus (HGV) and hepatitis C virus (HCV) and its clinical implication was investigated and the difference in the positive rate of HGV RNA and HCV RNA between plasma and peripheral blood mononuclear cells (PBMCs) observed. By using reverse transcriptase polymerase chain reaction (RT-PCR) assay, HCV-RNA and HGV-RNA in plasma and PBMCs of 72 patients with hepatitis C was detected. It was showed that HGV RNA was positive in plasma of 11 patients, in PBMCs of 15 patients, and simultaneously in both of plasma and PBMCs of 10 patients with the co-infection rate being 22.2 %. Nine patients were both HGV RNA and HCV RNA positive in plasma, 11 patients were both HGV RNA and HCV RNA positive in PBMC, and 6 patients were both HGV RNA and HCV RNA positive in both plasma and PBMC with the positive rate being 12.4 %, 15.3% and 8.3 % respectively. The positive rate of both HGV RNA and HCV RNA in PBMCs was higher than in plasma. It was concluded that the HGV co-infection rate in the patients with hepatitis C was 22.2 %. Simultaneous examination of plasma and PBMC can improve clinically detectable rate.
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References
1997,24:19
J, E. F, T. 2, 1995. 343–361
1999. 62–72
Tong C Y, Sallam T A, Williams Het al. Hepatitis G virus RNA and its relation to hepatitis C infection in adult haemophilic patients. Br J Haematol, 1997,99:195
Marrone A, Shih J W, Nakatsuji Yet al. Serum hepatitis G virus RNA in patients with chronic viral hepatitis. Am J Gastroenterol, 1997, 92: 1992
Oshita M, Mita E, Hayashi N. Coinfection of hepatitis C virus and hepatits G virus in patients with chronic hepatitis. Nippon Rinsho, 1997, 55: 617
Sheng L, Soumillion A, Peerlinck Ket al. Hepatitis G viral RNA in serum and in peripheral blood mononuclear cells and its relation to HCV RNA in patients with clotting disorders. Thromb Haemost, 1997,77:868
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Shuli, L., Linglan, Z., Duande, L. et al. Hepatitis G viral RNA co-infection in plasma and peripheral blood mononuclear cells in patients with hepatitis C. Current Medical Science 21, 238–239 (2001). https://doi.org/10.1007/BF02886441
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DOI: https://doi.org/10.1007/BF02886441